C/Ebp Homologous Protein Investigation in the Serum and Cerebro-Spinal Fluid of Relapsing-Remitting Multiple Sclerosis Patients

C/Ebp Homologous Protein Investigation in the Serum and Cerebro-Spinal Fluid of Relapsing-Remitting Multiple Sclerosis Patients Publisher Pubmed

Karami M¹ ; Aleagha MSE² ; Seidkhaninahal A³ ; Bakhtiyari S³ ; Noorizadeh A³ ; Harirchian MH⁴ ; Siroos B⁴ ; Balood M¹ ; Khosravi A⁵

Show Affiliations

1. Department of Clinical Biochemistry, AJA University of Medical Sciences, Tehran, Iran
2. Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3. Department of Clinical Biochemistry, Faculty of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran
4. Department of Neurology, Iranian Centre of Neurological Research, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Clinical Immunology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran

Source: Journal of Clinical Neuroscience Published:2019

Abstract

The exact determination of endoplasmic reticulum (ER) stress-associated proteins is not completely elucidated in the multiple sclerosis (MS) patients. We measured CHOP concentrations in the serum and cerebro-spinal fluid (CSF) of relapsing-remitting MS (RRMS) patients (n = 20) in comparison with the non-MS control group (n = 20) to determine whether this marker could be detected in the body fluids of RRMS patients. CHOP marker was not detectable in all harvested CSF samples. However, its levels were detectable in all serums harvested from both non-MS and RRMS patients and its levels in the latter group were not significantly higher than those of the non-MS control group (P value = 0.265). CHOP was not detectable in the CSF of RRMS patients in spite of the recent reports on the RRMS autopsies. Additionally, there were not any significant correlations (Spearman's correlation) between both of EDSS score and age with CHOP serum concentrations in all subjects. © 2018 Elsevier Ltd

2. Plp1 Mutations in Patients With Multiple Sclerosis: Identification of a New Mutation and Potential Pathogenicity of the Mutations, Journal of Clinical Medicine (2018)

3. Increased Expression of Endoplasmic Reticulum Stress-Related Caspase-12 and Chop in the Hippocampus of Eae Mice, Brain Research Bulletin (2019)

Experts (# of related papers)

Farshid Noorbakhsh (1)

Mohammad Hossein Harirchian (1)

Style	Citing Format
MLA	Karami M, et al.. "C/Ebp Homologous Protein Investigation in the Serum and Cerebro-Spinal Fluid of Relapsing-Remitting Multiple Sclerosis Patients." Journal of Clinical Neuroscience, vol. 59, no. , 2019, pp. 51-54.
APA	Karami M, Aleagha MSE, Seidkhaninahal A, Bakhtiyari S, Noorizadeh A, Harirchian MH, Siroos B, Balood M, Khosravi A (2019). C/Ebp Homologous Protein Investigation in the Serum and Cerebro-Spinal Fluid of Relapsing-Remitting Multiple Sclerosis Patients. Journal of Clinical Neuroscience, 59(), 51-54.
Chicago	Karami M, Aleagha MSE, Seidkhaninahal A, Bakhtiyari S, Noorizadeh A, Harirchian MH, Siroos B, Balood M, Khosravi A. "C/Ebp Homologous Protein Investigation in the Serum and Cerebro-Spinal Fluid of Relapsing-Remitting Multiple Sclerosis Patients." Journal of Clinical Neuroscience 59, no. (2019): 51-54.
Harvard	Karami M et al. (2019) 'C/Ebp Homologous Protein Investigation in the Serum and Cerebro-Spinal Fluid of Relapsing-Remitting Multiple Sclerosis Patients', Journal of Clinical Neuroscience, 59(), pp. 51-54.
Vancouver	Karami M, Aleagha MSE, Seidkhaninahal A, Bakhtiyari S, Noorizadeh A, Harirchian MH, et al.. C/Ebp Homologous Protein Investigation in the Serum and Cerebro-Spinal Fluid of Relapsing-Remitting Multiple Sclerosis Patients. Journal of Clinical Neuroscience. 2019;59():51-54.
BibTex	@article{ author = {Karami M and Aleagha MSE and Seidkhaninahal A and Bakhtiyari S and Noorizadeh A and Harirchian MH and Siroos B and Balood M and Khosravi A}, title = {C/Ebp Homologous Protein Investigation in the Serum and Cerebro-Spinal Fluid of Relapsing-Remitting Multiple Sclerosis Patients}, journal = {Journal of Clinical Neuroscience}, volume = {59}, number = {}, pages = {51-54}, year = {2019} }
RIS	TY - JOUR AU - Karami M AU - Aleagha MSE AU - Seidkhaninahal A AU - Bakhtiyari S AU - Noorizadeh A AU - Harirchian MH AU - Siroos B AU - Balood M AU - Khosravi A TI - C/Ebp Homologous Protein Investigation in the Serum and Cerebro-Spinal Fluid of Relapsing-Remitting Multiple Sclerosis Patients JO - Journal of Clinical Neuroscience VL - 59 IS - SP - 51 EP - 54 PY - 2019 ER -

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