Association Study of Two Functional Single Nucleotide Polymorphisms of Neuropeptide Y Gene With Multiple Sclerosis

Association Study of Two Functional Single Nucleotide Polymorphisms of Neuropeptide Y Gene With Multiple Sclerosis Publisher Pubmed

Mohammadi SM¹ ; Shirvani Farsani Z² ; Dosti R³ ; Sahraian MA³ ; Behmanesh M¹

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1. Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
2. Department of Genetics, Faculty of Biological Sciences, Shahid Beheshti University, Tehran, IR, Iran
3. MS Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran

Source: Neuropeptides Published:2016

Abstract

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by brain inflammation, demyelination and axonal loss. Neuropeptide Y (NPY) has a critical role in the maintenance of homeostasis in the immune system and coping of stress condition. In the current study we analyzed 188 patients suffering from MS and 204 unrelated healthy controls for two functional single nucleotide polymorphisms (SNPs), NPY 20T > C (rs16139) and NPY -485 T > C (rs16147) using PCR-RFLP and Mismatch PCR-RFLP methods. Our results demonstrated that homozygocity in the minor allele for NPY -485 T > C polymorphism is associated with the MS risk in patients in compare with healthy controls (CC vs. TT, P = 0.033; CC vs. TT + TC, P = 0.02). In addition, by comparison with allele T, the frequency of NPY -485C allele was higher in cases than in control subjects and present increased risk of MS, but statistically significant was borderline (P = 0.053). The stratification for disease progression revealed a significant difference in the allelic and genotypic distribution between subgroups of MS and controls. The frequency of the CC genotype and C allele was higher in the primary progressive MS patients when compared with control group (CC vs. TT, P = 0.019; CC vs. TT + TC, P = 0.008; C vs. T, P = 0.022). In addition, the frequency of CC genotype was higher in the relapsing remitting MS patients when compared with control group (CC vs. TT, P = 0.034; CC vs. TT + TC, P = 0.016). Haplotype analysis demonstrated that the haplotype 3 (CT) is more common in RR MS (P = 0.041), and PP MS (P = 0.031) than control group. In conclusion, the obtained results demonstrate the probable role of NPY SNPs in susceptibility to MS within the Iranian population. © 2016 Elsevier Ltd

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Mohammad Ali Sahraian (14)

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Style	Citing Format
MLA	Mohammadi SM, et al.. "Association Study of Two Functional Single Nucleotide Polymorphisms of Neuropeptide Y Gene With Multiple Sclerosis." Neuropeptides, vol. 60, no. , 2016, pp. 45-50.
APA	Mohammadi SM, Shirvani Farsani Z, Dosti R, Sahraian MA, Behmanesh M (2016). Association Study of Two Functional Single Nucleotide Polymorphisms of Neuropeptide Y Gene With Multiple Sclerosis. Neuropeptides, 60(), 45-50.
Chicago	Mohammadi SM, Shirvani Farsani Z, Dosti R, Sahraian MA, Behmanesh M. "Association Study of Two Functional Single Nucleotide Polymorphisms of Neuropeptide Y Gene With Multiple Sclerosis." Neuropeptides 60, no. (2016): 45-50.
Harvard	Mohammadi SM et al. (2016) 'Association Study of Two Functional Single Nucleotide Polymorphisms of Neuropeptide Y Gene With Multiple Sclerosis', Neuropeptides, 60(), pp. 45-50.
Vancouver	Mohammadi SM, Shirvani Farsani Z, Dosti R, Sahraian MA, Behmanesh M. Association Study of Two Functional Single Nucleotide Polymorphisms of Neuropeptide Y Gene With Multiple Sclerosis. Neuropeptides. 2016;60():45-50.
BibTex	@article{ author = {Mohammadi SM and Shirvani Farsani Z and Dosti R and Sahraian MA and Behmanesh M}, title = {Association Study of Two Functional Single Nucleotide Polymorphisms of Neuropeptide Y Gene With Multiple Sclerosis}, journal = {Neuropeptides}, volume = {60}, number = {}, pages = {45-50}, year = {2016} }
RIS	TY - JOUR AU - Mohammadi SM AU - Shirvani Farsani Z AU - Dosti R AU - Sahraian MA AU - Behmanesh M TI - Association Study of Two Functional Single Nucleotide Polymorphisms of Neuropeptide Y Gene With Multiple Sclerosis JO - Neuropeptides VL - 60 IS - SP - 45 EP - 50 PY - 2016 ER -

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