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Aerobic Training With Naringin Supplementation Improved Spatial Cognition Via H2s Signaling Pathway in Alzheimer’S Disease Model Rats Publisher Pubmed



Salehpour M1 ; Ashabi G2 ; Kashef M1 ; Marashi ES1 ; Ghasemi T1
Authors
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Authors Affiliations
  1. 1. Department of Sport and Exercise Physiology, Faculty of Sport Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran
  2. 2. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Experimental Aging Research Published:2023


Abstract

Objectives: This study examined the effects of one-month naringin administration and exercise training on cognitive impairment and H2S signaling pathway in an Amyloid β (Aβ)-injected rat. Methods: Rats were divided into four groups: control group; rats underwent Aβ microinjection surgery, exercise group; rats underwent Aβ microinjection surgery and trained by treadmill for four weeks, naringin group; rats underwent Aβ microinjection surgery, and rats orally administrated 80 mg.kg−1 naringin for four weeks, naringin+exercise group; rats underwent Aβ microinjection surgery and were trained by treadmill for four weeks, and also, rats orally administrated 80 mg.kg−1 naringin for four weeks. After one month of treatment, spatial learning and memory were measured, and then hippocampi were sampled. S-adenosylmethionine (SAM), cystathionine-β-synthase (CBS), hydrogen sulfide (H2S) levels, and neuronal death were detected in the hippocampi of rats. Results: Naringin and exercise improved spatial learning (latency time, P < .001) and memory (P < .001) in the Morris Water Maze test in Aβ-injected rats compared with the control group. SAM (P < .01), CBS (P < .001), and H2S (P < .01) levels are increased in the naringin+exercise group compared with the control group. Conclusion: The result of this study supports the effect of exercise and/or naringin to improve cognitive dysfunction and cell death through the production of H2S. © 2022 Taylor & Francis Group, LLC.
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