Long-Term Behavioral, Histological, Biochemical and Hematological Evaluations of Amyloid Beta-Induced Alzheimer’S Disease in Rat

Long-Term Behavioral, Histological, Biochemical and Hematological Evaluations of Amyloid Beta-Induced Alzheimer’S Disease in Rat Publisher Pubmed

Kheirbakhsh R¹ ; Haddadi M² ; Muhammadnejad A¹ ; Abdollahi A³ ; Shahi F⁴ ; Amanpourgharaei B^{5, 6} ; Abrahimhabibi A⁷ ; Barati T¹ ; Amanpour S¹

Show Affiliations

1. Cancer Biology Research Center, Cancer research Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
2. Vali-e-Asr Reproductive Health research center, Tehran University of Medical Sciences, Tehran, Iran
3. Dept. of Pathology, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
4. Islamic Azad University, Tehran Medical Branch, Tehran, Iran
5. Neuroimaging and Analysis Group, Research Center for Molecular and Cellular imaging, Tehran University of Medical Sciences, Tehran, Iran
6. International Graduate School of Neuroscience, Ruhr University, Bochum, Germany
7. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Acta Neurobiologiae Experimentalis Published:2018

Abstract

Alzheimer’s disease (AD) is a mental impairment and neural degeneration which causes progressive loss of memory and cognitive functions. This age-dependent illness is associated with extracellular amyloid plaques accumulation and twisted neurofibrillary tangles. Amyloid plaques are experimentally generated in animal models in order to investigate the disease process. In this study, we followed a rat model of AD for over a year. Wistar rats were divided randomly into two groups as control group (surgery without injection Aβ), and experimental group (two-sided intrahippocampal amyloid-beta injection into hippocampus). From each group, three animals were investigated 42 days after injection, and the remaining four animals were studied after one year. All animals were tested for learning abilities and memory. Finally, samples from blood, brain, heart, kidney, liver, colon and spleen were examined. In the experimental group, the size of amyloid plaques were increased significantly after one year and learning abilities and memory were concomitantly decreased. Onsets of various other conditions such as liver and kidney disorders, diabetes, and metabolic syndrome were observed, which indicates that the animals may be prone to cardiovascular disorders and ischemia. © 2018 by Acta Neurobiologiae Experimentalis.

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Style	Citing Format
MLA	Kheirbakhsh R, et al.. "Long-Term Behavioral, Histological, Biochemical and Hematological Evaluations of Amyloid Beta-Induced Alzheimer’S Disease in Rat." Acta Neurobiologiae Experimentalis, vol. 78, no. 1, 2018, pp. 51-59.
APA	Kheirbakhsh R, Haddadi M, Muhammadnejad A, Abdollahi A, Shahi F, Amanpourgharaei B, Abrahimhabibi A, Barati T, Amanpour S (2018). Long-Term Behavioral, Histological, Biochemical and Hematological Evaluations of Amyloid Beta-Induced Alzheimer’S Disease in Rat. Acta Neurobiologiae Experimentalis, 78(1), 51-59.
Chicago	Kheirbakhsh R, Haddadi M, Muhammadnejad A, Abdollahi A, Shahi F, Amanpourgharaei B, Abrahimhabibi A, Barati T, Amanpour S. "Long-Term Behavioral, Histological, Biochemical and Hematological Evaluations of Amyloid Beta-Induced Alzheimer’S Disease in Rat." Acta Neurobiologiae Experimentalis 78, no. 1 (2018): 51-59.
Harvard	Kheirbakhsh R et al. (2018) 'Long-Term Behavioral, Histological, Biochemical and Hematological Evaluations of Amyloid Beta-Induced Alzheimer’S Disease in Rat', Acta Neurobiologiae Experimentalis, 78(1), pp. 51-59.
Vancouver	Kheirbakhsh R, Haddadi M, Muhammadnejad A, Abdollahi A, Shahi F, Amanpourgharaei B, et al.. Long-Term Behavioral, Histological, Biochemical and Hematological Evaluations of Amyloid Beta-Induced Alzheimer’S Disease in Rat. Acta Neurobiologiae Experimentalis. 2018;78(1):51-59.
BibTex	@article{ author = {Kheirbakhsh R and Haddadi M and Muhammadnejad A and Abdollahi A and Shahi F and Amanpourgharaei B and Abrahimhabibi A and Barati T and Amanpour S}, title = {Long-Term Behavioral, Histological, Biochemical and Hematological Evaluations of Amyloid Beta-Induced Alzheimer’S Disease in Rat}, journal = {Acta Neurobiologiae Experimentalis}, volume = {78}, number = {1}, pages = {51-59}, year = {2018} }
RIS	TY - JOUR AU - Kheirbakhsh R AU - Haddadi M AU - Muhammadnejad A AU - Abdollahi A AU - Shahi F AU - Amanpourgharaei B AU - Abrahimhabibi A AU - Barati T AU - Amanpour S TI - Long-Term Behavioral, Histological, Biochemical and Hematological Evaluations of Amyloid Beta-Induced Alzheimer’S Disease in Rat JO - Acta Neurobiologiae Experimentalis VL - 78 IS - 1 SP - 51 EP - 59 PY - 2018 ER -

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