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Factors Associated With Depressive Symptoms in Young Adults With Coronary Artery Disease: Tehran Heart Center's Premature Coronary Atherosclerosis Cohort (Thc-Pac) Study



Abbasi SH1 ; Kassaian SE1 ; Sadeghian S1 ; Karimi A1 ; Saadat S2 ; Peyvandi F3, 4 ; Jalali A1 ; Davarpasand T1 ; Akhondzadh S5 ; Shahmansouri N1 ; Lotfitokaldany M1 ; Abchouyeh MA1 ; Isfahani FA1 ; Rosendaal F6
Authors
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Authors Affiliations
  1. 1. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Sina Trauma Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Milan, Italy
  4. 4. Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Milan, Italy
  5. 5. Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Clinical Epidemiology and Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, Netherlands

Source: Iranian Journal of Psychiatry Published:2016

Abstract

Objective: Depressed coronary artery disease (CAD) patients may experience a poorer prognosis than non-depressed patients. The aim of this study was to find the associated factors for depressive symptoms in young adults with CAD. Method: This was a cross-sectional study within Tehran Heart Center's Premature Coronary Atherosclerosis Cohort (THC-PAC) study. Young adult CAD patients (men ≤ 45 year-old and women ≤ 55 year-old) were visited from March 2013 to February 2014. Demographic, clinical and laboratory data were collected and all patients were asked to fill in the Beck Depression Inventory II. Informed consent was obtained from all participants. A logistic regression model was used to find multiple associated factors of depressive symptoms. Results: Seven hundred seventy patients (mean ±SD age: 45.34 ±5.75 y, men: 47.7%) were visited. The point prevalence of depressive symptoms was 46.9% in women and 30.2% in men (p < 0.001). Logistic regressions model revealed that the most important associated factors for depressive symptoms in the male premature CAD patients were opium usage (OR: 2.4, 95% CI: 1.33-4.43), major adverse cardiac events (MACE) (OR: 2.2, 95% CI: 1.17-3.93), initial coronary artery bypass grafting (CABG) treatment (OR: 2.1, 95% CI: 1.07-4.06), positive family history for CAD (OR: 1.8, 95% CI: 1.11-3.01) and cigarette smoking (OR: 1.7, 95% CI: 0.97-2.98). Hypertension showed a protective role in this group of patients (OR = 0.5, CI = 0.29-0.92). In the female patients, hypertension (OR = 1.5, CI = 0.96-2.22) and body mass index (BMI) (OR = 1.1, CI = 1.02-1.10) were associated with depressive symptoms. Conclusion: In premature CAD male patients, opium usage, MACE, initial CABG treatment, positive family history for CAD and cigarette smoking were associated with depressive symptoms; and hypertension and BMI were associated with depressive symptoms in women.
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1. Factors Associated With Anxiety in Premature Coronary Artery Disease Patients: Thc-Pac Study, Acta Medica Iranica (2016)
2. Effect of Rehabilitation Continuous and Interval Aerobic Exercise on Depression and Anxiety in Patients With Cardiac Diseases After Coronary Artery Bypass Surgery, Iranian Journal of Psychiatry and Clinical Psychology (2019)
3. Introducing the Tehran Heart Center's Premature Coronary Atherosclerosis Cohort: Thc-Pac Study, Journal of Tehran University Heart Center (2015)
4. Role of Heart and Its Diseases in the Etiology of Depression According to Avicenna’S Point of View and Its Comparison With Views of Classic Medicine, International Journal of Preventive Medicine (2015)
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