Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects and Safety of Resveratrol Supplementation in Older Adults: A Comprehensive Systematic Review Publisher Pubmed



Yadegar S1 ; Mohammadi F1 ; Yadegar A1 ; Mohammadi Naeini A1 ; Ayati A2 ; Milan N3 ; Tayebi A4 ; Seyedi SA1 ; Nabipoorashrafi SA1 ; Rabizadeh S1 ; Esteghamati A1 ; Nakhjavani M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Center for Orthopedic Trans-disciplinary Applied Research (COTAR), Shariaty Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Cardiovascular Research Center, Alborz University of Medical Sciences, Alborz, Iran

Source: Phytotherapy Research Published:2024


Abstract

Resveratrol (RSV) has garnered significant attention in recent years due to its potential benefits against chronic diseases. However, its effects and safety in older adults have not been comprehensively studied. This study aimed to determine the effects and safety of RSV supplementation in older adults. MEDLINE/PubMed, Scopus, and Web of Science databases were comprehensively searched for eligible studies. Studies were enrolled if they were randomized clinical trials and had incorporated RSV supplementation for older adults. Two independent authors conducted the literature search, and eligibility was determined according to the PICOS framework. Study details, intervention specifics, and relevant outcomes were collected during the data collection. The Cochrane RoB-2 tool was used to evaluate the risk of bias. This review included 10 studies. The combination of RSV and exercise improved exercise adaptation and muscle function in healthy older adults and physical performance and mobility measures in individuals with functional limitations. RSV showed potential neuroprotective effects in patients with Alzheimer's disease. In overweight individuals, RSV demonstrated a positive impact on cognitive function, but it increased some biomarkers of cardiovascular disease risk at high doses. In older adults with diabetes and those with peripheral artery disease (PAD), RSV was not more effective than placebo. No study reported significant adverse events following RSV treatment. RSV can improve various health parameters in age-related health conditions. However, the optimal dosage, long-term effects, and potential interactions with medications still need to be investigated through well-designed RCTs. © 2024 John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. Resveratrol Supplementation Significantly Influences Obesity Measures: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials, Obesity Reviews (2019)
2. Resveratrol Supplementation Decreases Blood Glucose Without Changing the Circulating Cd14 + Cd16 + Monocytes and Inflammatory Cytokines in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Study, Nutrition Research (2018)
3. Resveratrol and the Mitochondria: From Triggering the Intrinsic Apoptotic Pathway to Inducing Mitochondrial Biogenesis, a Mechanistic View, Biochimica et Biophysica Acta - General Subjects (2016)
4. Plant-Derived Natural Agents As Dietary Supplements for the Regulation of Glycosylated Hemoglobin: A Review of Clinical Trials, Clinical Nutrition (2020)
5. The Effects of Resveratrol on Lipid Profiles and Liver Enzymes in Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Lipids in Health and Disease (2020)
6. Resveratrol As a Potential Protective Compound Against Skeletal Muscle Insulin Resistance, Heliyon (2023)
7. Effect of Resveratrol on Metabolic Syndrome Components: A Systematic Review and Meta-Analysis, Reviews in Endocrine and Metabolic Disorders (2019)
8. Effect of Resveratrol Supplementation on Inflammatory Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Clinical Therapeutics (2018)
Experts (# of related papers)
View all Related Experts
Reza Meshkani (5)
Shadi Sadat Seyyedebrahimi (2)
Other Related Docs
9. Effects of Resveratrol Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials, International Journal of Clinical Practice (2021)
10. Effects of Resveratrol on Nonmelanoma Skin Cancer (Nmsc): A Comprehensive Review, Food Science and Nutrition (2024)
11. The Effects of Resveratrol on Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Endocrine# Metabolic and Immune Disorders - Drug Targets (2020)
12. Therapeutic Effect of Resveratrol Supplementation on Oxidative Stress: A Systematic Review and Meta-Analysis of Randomised Controlled Trials, Postgraduate Medical Journal (2020)
13. Effect of Resveratrol on C-Reactive Protein: An Updated Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2021)
14. Resveratrol-Loaded Nanocarriers: Characteristics, Sources, Health Effects, Recent Delivery Systems, and Their Food and Biomedical Applications, Food Bioscience (2024)
15. The Effects of Resveratrol on Markers of Oxidative Stress in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Acta Diabetologica (2018)
16. Targeting Erk Signaling Pathway by Polyphenols As Novel Therapeutic Strategy for Neurodegeneration, Food and Chemical Toxicology (2018)
17. Therapeutic Effects of Resveratrol and Omega-3 in Mice Atherosclerosis: Focus on Histopathological Changes, BMC Complementary Medicine and Therapies (2023)
18. Effects of Silymarin Supplementation on Liver and Kidney Functions: A Systematic Review and Dose–Response Meta-Analysis, Phytotherapy Research (2024)
19. Natural Activators of Adenosine 5′-Monophosphate (Amp)-Activated Protein Kinase (Ampk) and Their Pharmacological Activities, Food and Chemical Toxicology (2018)
20. Impacts of Supplementation With Silymarin on Cardiovascular Risk Factors: A Systematic Review and Dose–Response Meta-Analysis, Antioxidants (2024)
21. Impact of Polyphenols on Heart Failure and Cardiac Hypertrophy: Clinical Effects and Molecular Mechanisms, Frontiers in Cardiovascular Medicine (2023)
22. Effects of Resveratrol Supplementation on Serum Concentrations of Plasminogen Activator Inhibitor-1, Fibroblast Growth Factor 21, and Adiponectin in Patients With Nonalcoholic Fatty Liver Disease, BMC Nutrition (2025)
23. The Effects of Quinoa Seed Supplementation on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Controlled Clinical Trials, Phytotherapy Research (2021)
24. “Anatomic Patella Design Versus Medialized Dome Design in the Modern Posterior Stabilized (Attune) Total Knee Arthroplasty: A Systematic Review and Meta-Analysis”, Journal of Orthopaedic Surgery and Research (2025)
25. Pleotropic Effects of Polyphenols in Cardiovascular System, Biomedicine and Pharmacotherapy (2020)
26. Does Ginger Supplementation Lower Blood Pressure? a Systematic Review and Meta-Analysis of Clinical Trials, Phytotherapy Research (2019)
27. Full-Ceramic Resin-Bonded Fixed Dental Prostheses: A Systematic Review, Journal of Applied Biomaterials and Functional Materials (2024)
28. Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases, Frontiers in Physiology (2020)
29. Effect of Resveratrol on Inflammatory Cytokines: A Meta-Analysis of Randomized Controlled Trials, European Journal of Pharmacology (2021)
30. What Is the Influence of Cinnamon Supplementation on Liver Enzymes? a Systematic Review and Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2021)
31. Effect of Resveratrol on Cognitive and Memory Performance and Mood: A Meta-Analysis of 225 Patients, Pharmacological Research (2018)
32. The Effects of Magnesium Supplementation on Obesity Measures in Adults: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, Critical Reviews in Food Science and Nutrition (2020)
33. Potential Nephroprotective Effects of Resveratrol in Drug Induced Nephrotoxicity: A Narrative Review of Safety and Efficacy Data, Advances in Traditional Medicine (2020)
34. Resveratrol As Adjunctive Therapy in Treatment of Irritability in Children With Autism: A Double-Blind and Placebo-Controlled Randomized Trial, Journal of Clinical Pharmacy and Therapeutics (2020)
35. Effects of Melissa Officinalis (Lemon Balm) Consumption on Serum Lipid Profile: A Meta-Analysis of Randomized Controlled Trials, BMC Complementary Medicine and Therapies (2024)
36. Effect of Oral Resveratrol-Loaded Nanoliposomes on Hyperlipidemia Via Toll-Like Receptor 3 and Tir Domain-Containing Adaptor Inducing Interferon-Β Protein Expression in an Animal Model, Journal of Liposome Research (2025)
37. The Effects of Silymarin on the Features of Cardiometabolic Syndrome in Adults: A Systematic Review and Meta-Analysis, Phytotherapy Research (2022)
38. Effects of Garlic Supplementation on Oxidative Stress and Antioxidative Capacity Biomarkers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2021)
39. Barriers and Enablers of Adherence to High-Intensity Interval Training Among Patients With Cancer: A Systematic Review and Meta-Analysis, British Journal of Sports Medicine (2024)
40. The Effect of Almond Intake on Cardiometabolic Risk Factors, Inflammatory Markers, and Liver Enzymes: A Systematic Review and Meta-Analysis, Phytotherapy Research (2022)
41. Therapeutic Effects of Resveratrol on Ischemia–Reperfusion Injury in the Nervous System, Neurochemical Research (2021)
42. Effects of Saffron (Crocus Sativus L.) Supplementation on Inflammatory Biomarkers: A Systematic Review and Meta-Analysis, Phytotherapy Research (2021)
43. Evaluating the Combination and Comparison of Ablative Fractional Lasers (Co2, Erbium-Yag) With Pulsed Dye Laser (Pdl) for Treating Hypertrophic Scars: A Systematic Review, Lasers in Medical Science (2025)
44. Self-Management Interventions For People With Multiple Sclerosis: A Systematic Review and Meta-Analysis Protocol, Health Science Reports (2023)
45. A Systematic Review and Meta-Analysis of Randomized Controlled Trials Investigating the Effect of the Curcumin and Piperine Combination on Lipid Profile in Patients With Metabolic Syndrome and Related Disorders, Phytotherapy Research (2023)
46. Resveratrol Adjunct Therapy for Negative Symptoms in Patients With Stable Schizophrenia: A Double-Blind, Randomized Placebo-Controlled Trial, International Journal of Neuropsychopharmacology (2020)
47. The Endocannabinoid System and Ngf Are Involved in the Mechanism of Action of Resveratrol: A Multi-Target Nutraceutical With Therapeutic Potential in Neuropsychiatric Disorders, Psychopharmacology (2016)
48. Effects of Berberine and Barberry on Selected Inflammatory Biomarkers in Adults: A Systematic Review and Dose–Response Meta-Analysis of Randomized Clinical Trials, Phytotherapy Research (2023)
49. Are There Clinical Differences Between 3D-Printed and Milled Complete Dentures? a Systematic Review and Meta-Analysis, International Dental Journal (2025)
50. Safety and Efficacy of Elotuzumab Combination Therapy for Patients With Multiple Myeloma: A Systematic Review and Meta-Analysis, Expert Review of Anticancer Therapy (2023)