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Effects of Resveratrol on Nonmelanoma Skin Cancer (Nmsc): A Comprehensive Review Publisher



Zamanian M1, 2 ; Shahbazi T3 ; Kazmi S4 ; Hussien B5, 6, 7 ; Sharma A8 ; Qasim M9 ; Hjazi A10 ; Sapaev I11, 12 ; Nouridanesh A2 ; Taheri N13 ; Golmohammadi M14
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Department of Dermatology, School of Medicine, Sina Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. Depatment of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Chandigarh Pharmacy College, Chandigarh Group of Colleges, Punjab, Mohali, India
  5. 5. Medical Laboratory Technique College, The Islamic University, Najaf, Iraq
  6. 6. Medical Laboratory Technique College, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq
  7. 7. Medical Laboratory Technique College, The Islamic University of Babylon, Babylon, Iraq
  8. 8. Department of Medicine, National Institute of Medical Sciences, NIMS University Rajasthan, Jaipur, India
  9. 9. Department of Anesthesia, College of Health and Medical Technololgy, Al-Ayen University Thi-Qar, Nasiriyah, Iraq
  10. 10. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
  11. 11. Tashkent Institute of Irrigation and Agricultural Mechanization Engineers, National Research University, Tashkent, Uzbekistan
  12. 12. New Uzbekistan University, Tashkent, Uzbekistan
  13. 13. School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  14. 14. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Food Science and Nutrition Published:2024


Abstract

Nonmelanoma skin cancer (NMSC) represents the most prevalent form of skin cancer globally, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being the most common types. The search for effective chemopreventive and therapeutic agents has led to the exploration of natural compounds, among which resveratrol (RES), a polyphenolic phytoalexin found in grapes, berries, peanuts, and red wine, has garnered significant attention. This comprehensive review aims to elucidate the effects of RES on NMSC, focusing on its mechanisms of action, efficacy in preclinical studies, and potential as a chemopreventive and therapeutic agent. RES exhibits promising chemopreventive and antineoplastic capabilities against NMSC through various mechanisms, including the induction of apoptosis, inhibition of cell proliferation, modulation of oxidative stress, and anti-inflammatory activities. Studies have demonstrated that RES can significantly enhance the effectiveness of traditional chemotherapeutic agents, such as 5-fluorouracil (5-FU), by inhibiting cellular proliferation and inducing apoptosis in cancerous cells. Furthermore, resveratrol's antioxidant properties may mitigate the impact of reactive oxygen species (ROS) triggered by UV exposure, thus reducing DNA damage and mutations associated with skin cancer development. In vitro and in vivo experiments have shown that RES can effectively hinder the growth and spread of various tumor cell types, including human cutaneous SCC A431 cells, and induce apoptosis. The development of advanced delivery systems, such as nanostructured lipid carriers and liposomes, has been recognized for their potential to enhance the therapeutic effects of RES, particularly its anticancer properties. In conclusion, RES presents a viable candidate for the prevention and treatment of NMSC, owing to its multifaceted mechanisms of action, including its ability to regulate oxidative stress, trigger apoptosis, and inhibit proliferation. However, further clinical studies are required to fully understand its effectiveness and safety in humans, as well as to optimize delivery methods for improved bioavailability and therapeutic outcomes. © 2024 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC.
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