Layered Double Hydroxide Nanoparticles As an Appealing Nanoparticle in Gene/Plasmid and Drug Delivery System in C2c12 Myoblast Cells

Layered Double Hydroxide Nanoparticles As an Appealing Nanoparticle in Gene/Plasmid and Drug Delivery System in C2c12 Myoblast Cells Publisher Pubmed

Yazdani P¹ ; Mansouri E¹ ; Eyvazi S² ; Yousefi V¹ ; Kahroba H³ ; Hejazi MS^{1, 3, 4} ; Mesbahi A¹ ; Tarhriz V¹ ; Abolghasemi MM⁵

Show Affiliations

1. Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
2. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
4. Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
5. Department of Chemistry, Faculty of Science, University of Maragheh, Maragheh, Iran

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2019

Abstract

Gene and drug delivery systems need crucial update in the issue of nanocarriers. Layered double hydroxides (LDHs) are known as biocompatible inorganic lamellar nanomaterials with versatile properties. In the present study, Zn/Al-LDH nanoparticle was synthesized and characterized by FTIR, XRD, SEM, TEM and Zeta potential tests and then intercalated with valproate and methyldopa by co-precipitation and ion exchange methods. These nanocarriers were applied as high activity nanolayers-based delivery systems. On the other hand, Zn/Al-LDH + plasmid/gene (pCEP4/Cdk9) evaluated on C2C12 myoblast cells. Co-operation loading indicated high efficiency of sorting and release of drugs. Additionally, the Real-Time PCR and Western blotting results for plasmid-gene (pCEP4/Cdk9) delivery showed that Zn/Al-LDH nanoparticles can be used as an effective carrier in cellular uptake and release of genes for gene therapy. Easy and cost-effective production of Zn/Al-LDH nanoparticles proposed them as potential alternatives for the traditional routs of drug/gene delivery. © 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Yazdani P, et al.. "Layered Double Hydroxide Nanoparticles As an Appealing Nanoparticle in Gene/Plasmid and Drug Delivery System in C2c12 Myoblast Cells." Artificial Cells# Nanomedicine and Biotechnology, vol. 47, no. 1, 2019, pp. 436-442.
APA	Yazdani P, Mansouri E, Eyvazi S, Yousefi V, Kahroba H, Hejazi MS, Mesbahi A, Tarhriz V, Abolghasemi MM (2019). Layered Double Hydroxide Nanoparticles As an Appealing Nanoparticle in Gene/Plasmid and Drug Delivery System in C2c12 Myoblast Cells. Artificial Cells# Nanomedicine and Biotechnology, 47(1), 436-442.
Chicago	Yazdani P, Mansouri E, Eyvazi S, Yousefi V, Kahroba H, Hejazi MS, Mesbahi A, Tarhriz V, Abolghasemi MM. "Layered Double Hydroxide Nanoparticles As an Appealing Nanoparticle in Gene/Plasmid and Drug Delivery System in C2c12 Myoblast Cells." Artificial Cells# Nanomedicine and Biotechnology 47, no. 1 (2019): 436-442.
Harvard	Yazdani P et al. (2019) 'Layered Double Hydroxide Nanoparticles As an Appealing Nanoparticle in Gene/Plasmid and Drug Delivery System in C2c12 Myoblast Cells', Artificial Cells# Nanomedicine and Biotechnology, 47(1), pp. 436-442.
Vancouver	Yazdani P, Mansouri E, Eyvazi S, Yousefi V, Kahroba H, Hejazi MS, et al.. Layered Double Hydroxide Nanoparticles As an Appealing Nanoparticle in Gene/Plasmid and Drug Delivery System in C2c12 Myoblast Cells. Artificial Cells# Nanomedicine and Biotechnology. 2019;47(1):436-442.
BibTex	@article{ author = {Yazdani P and Mansouri E and Eyvazi S and Yousefi V and Kahroba H and Hejazi MS and Mesbahi A and Tarhriz V and Abolghasemi MM}, title = {Layered Double Hydroxide Nanoparticles As an Appealing Nanoparticle in Gene/Plasmid and Drug Delivery System in C2c12 Myoblast Cells}, journal = {Artificial Cells# Nanomedicine and Biotechnology}, volume = {47}, number = {1}, pages = {436-442}, year = {2019} }
RIS	TY - JOUR AU - Yazdani P AU - Mansouri E AU - Eyvazi S AU - Yousefi V AU - Kahroba H AU - Hejazi MS AU - Mesbahi A AU - Tarhriz V AU - Abolghasemi MM TI - Layered Double Hydroxide Nanoparticles As an Appealing Nanoparticle in Gene/Plasmid and Drug Delivery System in C2c12 Myoblast Cells JO - Artificial Cells# Nanomedicine and Biotechnology VL - 47 IS - 1 SP - 436 EP - 442 PY - 2019 ER -

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