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The Helicobacter Pylori Genome Project: Insights Into H. Pylori Population Structure From Analysis of a Worldwide Collection of Complete Genomes Publisher Pubmed



Thorell K1 ; Munozramirez ZY2 ; Wang D3, 4 ; Sandovalmotta S5, 6, 7 ; Boscolo Agostini R8 ; Ghirotto S8 ; Torres RC9 ; Romerogallo J10 ; Krishna U10 ; Piazuelo MB10 ; Raaf N11 ; Bentolila F12 ; Aftab H13 ; Akada J14 Show All Authors
Authors
  1. Thorell K1
  2. Munozramirez ZY2
  3. Wang D3, 4
  4. Sandovalmotta S5, 6, 7
  5. Boscolo Agostini R8
  6. Ghirotto S8
  7. Torres RC9
  8. Romerogallo J10
  9. Krishna U10
  10. Piazuelo MB10
  11. Raaf N11
  12. Bentolila F12
  13. Aftab H13
  14. Akada J14
  15. Matsumoto T14
  16. Haesebrouck F15
  17. Colanzi RP16
  18. Bartelli TF17
  19. Nunes DN17
  20. Pelosof A17
  21. Sztokfisz CZ17
  22. Diasneto E17
  23. Assumpcao PP18
  24. Tishkov I19
  25. Mabeku LBK20
  26. Goodman KJ21
  27. Geary J21
  28. Cromarty TJ21
  29. Price NL21
  30. Quilty D22
  31. Corvalan AH23
  32. Serrano CA24
  33. Gonzalez R25
  34. Riquelme A25
  35. Garciacancino A26
  36. Parrasepulveda C26
  37. Bernal G27
  38. Castillo F28
  39. Goldstein AM4
  40. Hu N4
  41. Taylor PR4
  42. Bravo MM29
  43. Pazos A30
  44. Bravo LE31
  45. Wilson KT10
  46. Fox JG32
  47. Ramirezmayorga V33
  48. Molinacastro S33
  49. Duranbermudez S34
  50. Camposnunez C35
  51. Chavescervantes M35
  52. Tshibangukabamba E36, 37
  53. Tumba GD37
  54. Tshimpiwola A38
  55. De Jesus Ngomakisoko P38
  56. Ngoyi DM38, 39
  57. Cruz M40
  58. Hosking C40
  59. Abreu JJ41
  60. Varon C42
  61. Benejat L42
  62. Secka O43
  63. Link A44
  64. Malfertheiner P44
  65. Adinortey MB45
  66. Bockarie AS46
  67. Adinortey CA47
  68. Ofori EG48
  69. Sgouras DN49
  70. Martinezgonzalez B49
  71. Michopoulos S50
  72. Georgopoulos S51
  73. Hernandez E52
  74. Tacatic BV53
  75. Aguilar M54
  76. Dominguez RL55
  77. Morgan DR56
  78. Harardottir H57
  79. Gunnarsdottir AI57
  80. Gujonsson H57
  81. Jonasson JG57, 58
  82. Bjornsson ES57, 58
  83. Ballal M59
  84. Shetty V59, 60
  85. Miftahussurur M61
  86. Sugihartono T61
  87. Alfaray RI61
  88. Waskito LA61
  89. Fauzia KA61
  90. Syam AF62
  91. Maulahela H62
  92. Malekzadeh R63
  93. Sotoudeh M63
  94. Peretz A64, 65
  95. Azrad M64, 65
  96. On A65, 66
  97. De Re V67
  98. Zanussi S67
  99. Cannizzaro R68
  100. Canzonieri V69
  101. Shimura T70
  102. Tokunaga K71
  103. Osaki T71
  104. Kamiya S71
  105. Jadallah K72
  106. Matalka I72
  107. Igissinov N73
  108. Moldobaeva MS74
  109. Rakhat A74
  110. Choi IJ75
  111. Kim JG76
  112. Kim N77
  113. Song M4
  114. Leja M78, 79, 80
  115. Vangravs R78
  116. Skenders G78, 80
  117. Rudzite D80
  118. Rudule A78
  119. Vanags A79
  120. Kikuste I78
  121. Kupcinskas J81
  122. Skieceviciene J81
  123. Jonaitis L81
  124. Kiudelis G81
  125. Jonaitis P81
  126. Kiudelis V81
  127. Varkalaite G81
  128. Vadivelu J82, 83
  129. Loke MF82
  130. Vellasamy KM82
  131. Herreragoepfert R84
  132. Alonsolarraga JO85
  133. Yee TT86
  134. Htet K86
  135. Matsuhisa T87
  136. Shrestha PK88
  137. Ansari S89
  138. Abiodun O90
  139. Jemilohun C91
  140. Akande KO92
  141. Oluabiodun O93
  142. Magaji FA94
  143. Omotoso A95
  144. Osuagwu CC96
  145. Okonkwo U95
  146. Owoseni OO97
  147. Castaneda C98
  148. Castillo M99
  149. Velapatino B100
  150. Gilman RH101
  151. Krzyzek P102
  152. Gosciniak G102
  153. Pawelka D103
  154. Koronaglowniak I104
  155. Cichozlach H105
  156. Oleastro M106
  157. Figueiredo C107, 108, 109
  158. Machado JC107, 108, 109
  159. Ferreira RM107, 108
  160. Bordin DS110, 111, 112
  161. Livzan MA113
  162. Tsukanov VV114
  163. Tan P115, 116, 117
  164. Yeoh KG118, 119
  165. Zhu F118
  166. Ally R120, 121
  167. Haas R122
  168. Montes M123
  169. Fernandezreyes M123
  170. Tamayo E123
  171. Lizasoain J123
  172. Bujanda L124
  173. Lario S125, 126
  174. Ramirezlazaro MJ125, 126
  175. Calvet X125, 126
  176. Brunetmas E125, 126
  177. Domperarnal MJ127, 128
  178. Garciamateo S127, 128
  179. Abadbaroja D129
  180. Delgadoguillena P130
  181. Moreira L131
  182. Botargues J132
  183. Perezmartinez I133, 134
  184. Barreiroalonso E133, 135, 136
  185. Flores V137
  186. Gisbert JP138, 139
  187. Muro EA140
  188. Linares P141
  189. Martin V142
  190. Alcoba L141
  191. Fleitaskanonnikoff T143
  192. Altayeb HN144, 145
  193. Engstrand L146
  194. Enroth H147
  195. Keller PM148, 149
  196. Wagner K150
  197. Pohl D151
  198. Lee YC152
  199. Liou JM152
  200. Wu MS152
  201. Kocazeybek B153
  202. Saribas S153
  203. Tasci I154
  204. Demiryas S154
  205. Kepil N155
  206. Quiel L156
  207. Villagra M157
  208. Norton M158
  209. Johnson D158
  210. Huang RJ159
  211. Hwang JH159
  212. Szymczak W160
  213. Rajagopalan S160
  214. Asare E160
  215. Jacobs Jr WR160
  216. In H160, 161
  217. Bollag R162
  218. Lopez A162
  219. Kruse EJ163
  220. White J163
  221. Graham DY164
  222. Lane C165
  223. Gao Y165
  224. Fields PI165
  225. Gold BD166
  226. Cruzcorrea M167, 168
  227. Gonzalezpons M167
  228. Rodriguez LM169
  229. Tuan VP170
  230. Dung HDQ170
  231. Binh TT170
  232. Trang TTH171
  233. Van Khien V171
  234. Chen X172
  235. Raley C173
  236. Kessing B173
  237. Zhao Y172
  238. Tran B173
  239. Gutierrezescobar AJ4
  240. Wan Y3
  241. Hicks B3
  242. Zhu B3
  243. Yu K4
  244. Zhu B3
  245. Yeager M3
  246. Hutchinson A3
  247. Teshome K3
  248. Jones K3
  249. Luo W3
  250. Jehanne Q42
  251. Katsura Y174
  252. Gonzalezhormazabal P175
  253. Didelot X176
  254. Sheppard S177
  255. Tarazonasantos E178
  256. Marinoramirez L179
  257. Loh JT10
  258. Backert S180
  259. Naumann M181
  260. Abnet CC4
  261. Smet A182
  262. Berg DE183
  263. Chineroms A184, 185
  264. Comas I185, 186
  265. Martinezmartinez FJ186
  266. Zamudio R178, 187
  267. Lehours P42
  268. Megraud F42
  269. Yahara K188
  270. Blaser MJ189
  271. Vincze T190
  272. Morgan RD190
  273. Roberts RJ190
  274. Chanock SJ4
  275. Dekker JP191
  276. Torres J192
  277. Cover TL10, 193
  278. Noureen M194
  279. Fischer W122
  280. Vale FF195, 196
  281. Cherry JL197, 198
  282. Osada N199
  283. Fukuyo M200
  284. Arita M201
  285. Yamaoka Y14, 164
  286. Kobayashi I202
  287. Uchiyama I203
  288. Falush D9
  289. Camargo MC4
  290. Rabkin CS4
Show Affiliations
Authors Affiliations
  1. 1. Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden
  2. 2. Facultad de Ciencias Quimicas, Universidad Autonoma de Chihuahua, Chihuahua, Chihuahua, Mexico
  3. 3. Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, United States
  4. 4. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States
  5. 5. Instituto Nacional de Medicina Genomica, Ciudad de Mexico, Mexico
  6. 6. Consejo Nacional de Ciencia y Tecnologia, Catedras CONACYT, Ciudad de Mexico, Mexico
  7. 7. Centro de Ciencias de la Complejidad, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico
  8. 8. Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy
  9. 9. Centre for Microbes Development and Health, Institute Pasteur Shanghai, Shanghai, China
  10. 10. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States
  11. 11. Department of Natural and Life Sciences, Faculty of Sciences, University of Algiers 1 Benyoucef Benkhedda, Algiers, Algeria
  12. 12. Departamento de Medicina Interna, Hospital Aleman, Buenos Aires, Argentina
  13. 13. Department of Gastroenterology, Dhaka Medical College and Hospital, Dhaka, Bangladesh
  14. 14. Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan
  15. 15. Department of Pathobiology, Pharmacology and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium
  16. 16. Hospital Universitario Japones, Santa Cruz de la Sierra, Bolivia
  17. 17. A.C.Camargo Cancer Center, Sao Paulo, Sao Paulo, Brazil
  18. 18. Nucleo de Pesquisas em Oncologia, Universidade Federal do Para, Para, Belem, Brazil
  19. 19. Medical University of Sofia, Sofia, Bulgaria
  20. 20. Department of Biochemistry, University of Dschang, Dschang, Cameroon
  21. 21. Faculty of Medicine and Dentistry, Department of Medicine, University of Alberta, Edmonton, AB, Canada
  22. 22. Queen’s University, Kingston, ON, Canada
  23. 23. Department of Hematology and Oncology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
  24. 24. Department of Pediatric Gastroenterology and Nutrition, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
  25. 25. Department of Gastroenterology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
  26. 26. Facultad de Ciencias Biologicas, Universidad de Concepcion, Concepcion, Chile
  27. 27. Cancer Lab, Departamento de Ciencias Biomedicas, Facultad de Medicina, Universidad Catolica del Norte (Coquimbo), Chile, Coquimbo, Chile
  28. 28. Hospital Hanga Roa, Easter Island, Chile
  29. 29. Grupo de Investigacion en Biologia del Cancer, Instituto Nacional de Cancerologia, DC, Bogota, Colombia
  30. 30. Departamento de Biologia, Universidad de Narino, Narino, Pasto, Colombia
  31. 31. Escuela de Medicina, Universidad del Valle, Valle, Cali, Colombia
  32. 32. Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States
  33. 33. Instituto de Investigaciones en Salud, Universidad de Costa Rica, San Jose, Costa Rica
  34. 34. Laboratorio de Patologia General y Gastrointestinal (LABGIPAT), San Jose, Costa Rica
  35. 35. Servicio de Gastroenterologia y Endoscopia Digestiva, Hospital Clinica Biblica, San Jose, Costa Rica
  36. 36. Faculty of Medicine, Osaka Metropolitan University, Osaka, Japan
  37. 37. Faculty of Medicine, University of Mbuji-Mayi, Kasai-Oriental, Mbuji Mayi, Democratic Republic Congo
  38. 38. Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic Congo
  39. 39. Department of Parasitology, National Institute of Biomedical Research, Kinshasa, Democratic Republic Congo
  40. 40. Instituto de Microbiologia y Parasitologia, Universidad Autonoma de Santo Domingo, Santo Domingo, Dominican Republic
  41. 41. Dominican-Japanese Digestive Disease Center, Dr Luis E. Aybar Health and Hygiene City, Santo Domingo, Dominican Republic
  42. 42. Bordeaux Institute of Oncology, BRIC U1312, INSERM, Bordeaux, and National Reference Center for Campylobacters & Helicobacters, CHU de Bordeaux, Bordeaux, France
  43. 43. Medical Research Council Unit, The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, Gambia
  44. 44. Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
  45. 45. Department of Biochemistry, School of Biological Sciences, University of Cape Coast, Central Region, Cape Coast, Ghana
  46. 46. Department of Internal Medicine and Therapeutics, School of Medical Sciences, University of Cape Coast, Central Region, Cape Coast, Ghana
  47. 47. Department of Molecular Biology and Biotechnology, School of Biological Sciences, University of Cape Coast, Central Region, Cape Coast, Ghana
  48. 48. Department of Biology Education, Faculty of Science Education, University of Education, Winneba, Ghana
  49. 49. Laboratory of Medical Microbiology, Hellenic Pasteur Institute, Athens, Greece
  50. 50. Department of Gastroenterology, Alexandra Hospital, Athens, Greece
  51. 51. Department of Gastroenterology, Athens Medical, P. Faliron Hospital, Athens, Greece
  52. 52. Facultad de Ciencias Medicas, University of San Carlos of Guatemala, Guatemala City, Guatemala
  53. 53. Unidad de Gastroenterologia, Hospital Roosevelt, Guatemala City, Guatemala
  54. 54. Gastrocentro, S.A., Guatemala City, Guatemala
  55. 55. Departamento de Medicina Interna, Hospital de Occidente, Santa Rosa de Copan, Honduras
  56. 56. School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, United States
  57. 57. Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
  58. 58. University of Iceland, Reykjavik, Iceland
  59. 59. Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Karnataka, Manipal, India
  60. 60. Department of Medicine, University of Cambridge, Cambridge, United Kingdom
  61. 61. Universitas Airlangga, East Java, Surabaya, Indonesia
  62. 62. University of Indonesia, Jakarta, Indonesia
  63. 63. Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  64. 64. Clinical Microbiology Laboratory and Research Institute, Tzafon Medical Center, affiliated with Azrieli Faculty of Medicine, Bar Ilan University, Poriya, Israel
  65. 65. Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel
  66. 66. Pediatric Gastroenterology and Nutrition Unit, Tzafon Medical Center, Poriya, Israel
  67. 67. Unit of Immunopathology and Oncological Biomarkers, Centro di Riferimento Oncologico di Aviano, Aviano, Italy
  68. 68. Unit of Oncological Gastroenterology, Centro di Riferimento Oncologico di Aviano, Aviano, Italy
  69. 69. Unit of Pathology, Centro di Riferimento Oncologico di Aviano, Aviano, Italy
  70. 70. Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
  71. 71. School of Medicine, Kyorin University, Mitaka, Tokyo, Japan
  72. 72. Jordan University of Science and Technology, Ar-Ramtha, Jordan
  73. 73. Department of Surgical Diseases Internship, Astana Medical University, Nur-Sultan, Kazakhstan
  74. 74. Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan
  75. 75. Center for Gastric Cancer, National Cancer Center, Goyang, South Korea
  76. 76. Department of Internal Medicine, Chung-Ang University Hospital, Seoul, South Korea
  77. 77. College of Medicine, Seoul National University, Seoul, South Korea
  78. 78. Institute of Clinical and Preventive Medicine, University of Latvia, Riga, Latvia
  79. 79. Digestive Diseases Centre GASTRO, Riga, Latvia
  80. 80. Riga East University Hospital, Riga, Latvia
  81. 81. Department of Gastroenterology, Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
  82. 82. Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia
  83. 83. Medical Education Research and Development Unit, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia
  84. 84. Departamento de Patologia, Instituto Nacional de Cancerologia, Mexico City, Mexico
  85. 85. Servicio de Endoscopia, Instituto Nacional de Cancerologia, Mexico City, Mexico
  86. 86. Defence Services General Hospital, Yangon, Yangon Region, Yangon, Myanmar
  87. 87. Nippon Medical School, Tokyo, Japan
  88. 88. Department of Gastroenterology, Tribhuvan University Teaching Hospital, Maharajgunj Medical Campus, Kathmandu, Nepal
  89. 89. Division of Health Sciences, Higher Colleges of Technology, Abu Dhabi Women’s Campus, Abu Dhabi, United Arab Emirates
  90. 90. Department of Community Medicine, Babcock University, Ogun State, Ilishan, Nigeria
  91. 91. Department of Medicine, Babcock University, Ogun State, Ilishan, Nigeria
  92. 92. Department of Medicine, College of Medicine, University of Ibadan, Oyo, Ibadan, Nigeria
  93. 93. Department of Nursing, Crescent University, Ogun State, Abeokuta, Nigeria
  94. 94. University Teaching Hospital, University of Jos, Plateau, Jos, Nigeria
  95. 95. University of Calabar Teaching Hospital, Cross River, Calabar, Nigeria
  96. 96. University of Nigeria Teaching Hospital, Enugu State, Ituku-Ozalla, Nigeria
  97. 97. Department of Internal Medicine, Federal Medical Center Abeokuta, Ogun State, Abeokuta, Nigeria
  98. 98. Faculty of Health Sciences, Universidad Cientifica del Sur, Lima, Peru
  99. 99. Departamento de investigacion, Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru
  100. 100. Universidad Peruana Cayetano Heredia, Lima, Peru
  101. 101. Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States
  102. 102. Department of Microbiology, Wroclaw Medical University, Wroclaw, Poland
  103. 103. Department of Surgery Teaching, Wroclaw Medical University, Wroclaw, Poland
  104. 104. Department of Pharmaceutical Microbiology, Medical University of Lublin, Lublin, Poland
  105. 105. Department of Gastroenterology with Endoscopic Unit, Medical University of Lublin, Lublin, Poland
  106. 106. Instituto Nacional de Saude Dr. Ricardo Jorge, Lisboa, Portugal
  107. 107. Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
  108. 108. Instituto de Investigacao e Inovacao em Saude, Universidade do Porto, Porto, Portugal
  109. 109. Faculdade de Medicina da Universidade do Porto, Porto, Portugal
  110. 110. Department of Pancreatic, Biliary and Upper Digestive Tract Disorders, A. S. Loginov Moscow Clinical Scientific Center, Moscow, Russian Federation
  111. 111. Department of General Medical Practice and Family Medicine, Tver State Medical University, Moscow, Russian Federation
  112. 112. Department of Propaedeutic of Internal diseases and Gastroenterology A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation
  113. 113. Department of Faculty Therapy and Gastroenterology, Omsk State Medical University, Omsk, Russian Federation
  114. 114. Scientific Research Institute of Medical Problems of the North, Federal Research Centre “Krasnoyarsk Science Centre� of the Siberian Branch of Russian Academy of Science, Krasnoyarsk, Russian Federation
  115. 115. Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
  116. 116. Cancer and Stem Cell Biology Program, Duke NUS Medical School, Singapore, Singapore
  117. 117. Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore
  118. 118. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  119. 119. Department of Gastroenterology and Hepatology, National University Health System, Singapore, Singapore
  120. 120. Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa
  121. 121. University of the Witwatersrand, Johannesburg, South Africa
  122. 122. Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU Munich, Munich, Germany
  123. 123. Hospital Universitario Donostia, San Sebastian, Spain
  124. 124. Department of Gastroenterology, Bioodonostia Health Research Institute - Donostia University Hospital, Universidad del Pais Vasco (UPV/EHU), Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBERehd), San Sebastian, Spain
  125. 125. Digestive Diseases Unit, Parc Tauli Hospital Universitari. Institut d’Investigacio i Innovacio Parc Tauli (I3PT-CERCA), Universitat Autonoma de Barcelona, Barcelona, Spain
  126. 126. Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain
  127. 127. Lozano Blesa University Clinic Hospital, Zaragoza, Spain
  128. 128. Aragon Health Research Institute, Zaragoza, Spain
  129. 129. Miguel Servet University Hospital, Zaragoza, Spain
  130. 130. Hospital General de Granollers, Barcelona, Spain
  131. 131. Gastroenterology Department, Hospital Clinic of Barcelona, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas, Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona, Barcelona, Spain
  132. 132. Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain
  133. 133. Department of Gastroenterology, Hospital Universitario Central de Asturias, Asturias, Oviedo, Spain
  134. 134. Diet, Microbiota and Health Group, Instituto de Investigacion Sanitaria del Principado de Asturias, Asturias, Oviedo, Spain
  135. 135. Farmacology Group, Instituto de Investigacion Sanitaria del Principado de Asturias, Asturias, Oviedo, Spain
  136. 136. Instituto Universitario de Oncologia del Principado de Asturias, Asturias, Oviedo, Spain
  137. 137. Hospital General Universitario Gregorio Maranon, Madrid, Spain
  138. 138. Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain
  139. 139. Universidad Autonoma de Madrid, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas, Madrid, Spain
  140. 140. Gastroenterology Department, Hospital Universitario de Navarra, Navarra, Pamplona, Spain
  141. 141. Hospital de Leon, Leon, Spain
  142. 142. Institut of Biomedicine, University of Leon, Consortium for Biomedical Research in Epidemiology and Public Health, Leon, Spain
  143. 143. Instituto de Investigacion Sanitaria INCLIVA, Hospital Clinico Universitario de Valencia, Valencia, Spain
  144. 144. Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
  145. 145. Faculty of Medical laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan
  146. 146. Centre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden
  147. 147. University of Skovde, Skovde, Sweden
  148. 148. Institute for Infectious Diseases, University of Bern, Bern, Switzerland
  149. 149. Clinical Bacteriology/Mycology Unit, University Hospital Basel, Basel, Switzerland
  150. 150. Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland
  151. 151. Clinic for Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland
  152. 152. College of Medicine, National Taiwan University, Taipei City, Taiwan
  153. 153. Medical Microbiology Department, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey
  154. 154. General Surgery Department, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey
  155. 155. Medical Pathology Department, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey
  156. 156. Lawrence General Hospital, Lawrence, MA, United States
  157. 157. Carson Tahoe Regional Medical Center, Carson City, NV, United States
  158. 158. White River Medical Center, Batesville, AR, United States
  159. 159. Department of Medicine, Stanford University, Stanford, CA, United States
  160. 160. Albert Einstein College of Medicine, Bronx, NY, United States
  161. 161. Rutgers Cancer Institute, New Brunswick, NJ, United States
  162. 162. Georgia Cancer Center’s Biorepository, Augusta University, Augusta, Georgia
  163. 163. Augusta University Medical Center, Augusta, Georgia
  164. 164. Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX, United States
  165. 165. Enteric Diseases Laboratory Branch, Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States
  166. 166. Gi Care for Kids, LLC, Children’s Center for Digestive Healthcare, LLC, Atlanta, GA, United States
  167. 167. University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico
  168. 168. University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
  169. 169. Gastrointestinal and Other Cancers Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD, United States
  170. 170. Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh City, Viet Nam
  171. 171. Department of Hepatogastroenterology, 108 Military Central Hospital, Hanoi, Viet Nam
  172. 172. Sequencing Facility Bioinformatics Group, Bioinformatics and Computational Science Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, United States
  173. 173. Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States
  174. 174. Center for the Evolutionary Origins of Human Behavior, Kyoto University, Inuyama, Japan
  175. 175. Instituto de Ciencias Biomedicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, Chile
  176. 176. School of Life Sciences, University of Warwick, Coventry, United Kingdom
  177. 177. Department of Biology & Biochemistry, University of Bath, Bath, United Kingdom
  178. 178. Departamento de Genetica, Ecologia e Evolucao, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
  179. 179. National Institute on Minority Health and Health Disparities, Bethesda, MD, United States
  180. 180. Division of Microbiology, Department of Biology, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany
  181. 181. Institute of Experimental Internal Medicine, Otto-von-Guericke-Universitat Magdeburg, Magdeburg, Germany
  182. 182. Laboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium
  183. 183. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, United States
  184. 184. Genomics and Health Area, FISABIO – Public Health, Valencia, Spain
  185. 185. CIBER in Epidemiology and Public Health, Madrid, Spain
  186. 186. Tuberculosis Genomics Unit, Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Cientificas, Valencia, Spain
  187. 187. Quadram Institute Bioscience, Norwich, United Kingdom
  188. 188. National Institute of Infectious Diseases, Tokyo, Japan
  189. 189. Center for Advanced Biotechnology and Medicine, Rutgers University, New Brunswick, NJ, United States
  190. 190. New England Biolabs, Ipswich, MA, United States
  191. 191. Bacterial Pathogenesis and Antimicrobial Resistance Unit, National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States
  192. 192. Unidad de Investigacion en Enfermedades Infecciosas y Parasitarias, UMAE Pediatria, Instituto de Seguro Social, Mexico City, Mexico
  193. 193. Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, United States
  194. 194. Department of Genetics, SOKENDAI University, Shizuoka, Mishima, Japan
  195. 195. Pathogen Genome Bioinformatics and Computational Biology, Research Institute for Medicines, Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal
  196. 196. Instituto de Biosistemas e Ciencias Integrativas, Faculdade de Ciencias, Universidade de Lisboa, Lisboa, Portugal
  197. 197. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, United States
  198. 198. Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, MD, United States
  199. 199. Faculty of Information Science and Technology, Hokkaido University, Sapporo, Japan
  200. 200. Department of Molecular Oncology, Chiba University, Chiba, Japan
  201. 201. Bioinformation and DDBJ Center, National Institute of Genetics, Shizuoka, Mishima, Japan
  202. 202. Research Center for Micro-Nano Technology, Hosei University, Tokyo, Japan
  203. 203. National Institute for Basic Biology, National Institutes of Natural Sciences, Aichi, Japan

Source: Nature Communications Published:2023


Abstract

Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics. © 2023, The Author(s).