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The Metabolomics of Airway Diseases, Including Copd, Asthma and Cystic Fibrosis Publisher Pubmed



Nobakht M Gh BF1, 4 ; Aliannejad R2 ; Rezaeitavirani M1 ; Taheri S3 ; Oskouie AA4
Authors
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Authors Affiliations
  1. 1. Faculty of Paramedical Sciences, Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Pulmonary Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Chemistry and Chemical Engineering Research Center of Iran, Tehran, Iran
  4. 4. Faculty of Paramedical Sciences, Department of Basic Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Biomarkers Published:2015


Abstract

Chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis (CF) are characterized by airway obstruction and an inflammatory process. Reaching early diagnosis and discrimination of subtypes of these respiratory diseases are quite a challenging task than other chronic illnesses. Metabolomics is the study of metabolic pathways and the measurement of unique biochemical molecules generated in a living system. In the last decade, metabolomics has already proved to be useful for the characterization of several pathological conditions and offers promises as a clinical tool. In this article, we review the current state of the metabolomics of COPD, asthma and CF with a focus on the different methods and instrumentation being used for the discovery of biomarkers in research and translation into clinic as diagnostic aids for the choice of patient-specific therapies. © 2014 Informa UK Ltd.