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Helicobacter Pylori Acquisition Rates and the Associated Risk Factors Amongst Newlywed Couples; a Prospective Cohort Study in Tehran, Iran Publisher Pubmed



Hadji M1, 2 ; Mortazavi M1 ; Saberi S3 ; Esmaieli M3 ; Amini N4 ; Akrami R5 ; Daroudian R1 ; Shakeri F1 ; Khedmat H6 ; Pukkala E2 ; Mohammadi M3 ; Zendehdel K1, 7
Authors
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Authors Affiliations
  1. 1. Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Health Sciences Unit, Faculty of Social Sciences, Tampere University, Tampere, Finland
  3. 3. HPGC Research Group, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, United States
  5. 5. Department of Epidemiology & Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Tehran, Iran
  7. 7. Cancer Biology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Microbes and Infection Published:2022


Abstract

Background: The rates and routes of Helicobacter pylori transmission, in a high-prevalent country like Iran, with gastric cancer as the leading cause of male cancer mortality, are of great essence. Here, we have studied the H. pylori-associated risk factors and the likelihood of interspousal transmission. Methods: In a cohort of 686 young prewed couples, questionnaires were self-administered and serum samples were collected, for assessment of risk factors and H. pylori serostatus, at baseline and follow-up. Of the 475 H. pylori single- or double-seronegative couples, 201 returned for follow-up. The average follow-up duration was 2.2 (SD 0.6) years, with a total of 560.1 person-years. Logistic regression and Cox regression models were used to estimate the odds ratios (ORs) and hazard ratios (HRs). Results: The risk of infection was higher in men than women (OR: 1.3, 95% CI: 1.0–1.8) and among metropolitan than rural residents (OR = 1.4, 95% CI: 1.1–1.9). It was also significantly higher among those with three (OR = 1.6, 95% CI: 1.1–2.2), and four or more siblings (OR = 1.4, 95% CI: 1.0–1.9), in reference to those with one or no siblings. Adult H. pylori acquisition occurred in 10.9% (27/247) of the seronegative participants. The risk of the acquisition was significantly associated with age (P value for trend=0,000). It was also significantly lower among participants who had various degrees of education as compared to illiterate subjects (HR = 0.2, 95% CI: 0.1–0.9). Nevertheless, our analysis did not find any evidence for interspousal transmission (HR = 1.0, 95% CI: 0.4–2.2). Conclusion: Whilst H. pylori acquisition was detected in the young adult Iranian population, our findings did not support interspousal transmission, as a mode of acquisition. © 2022 Institut Pasteur
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