Lifetime Physical Activity Is Associated With Gut Bacteria and Brain Health in People With Multiple Sclerosis: Focus on Physical Activity Intensity

Lifetime Physical Activity Is Associated With Gut Bacteria and Brain Health in People With Multiple Sclerosis: Focus on Physical Activity Intensity Publisher Pubmed

Mokhtarzade M¹ ; Molanouri Shamsi M¹ ; Abolhasani M² ; Bakhshi B³ ; Sahraian MA² ; Hamzeh Shalamzari M¹ ; Soudi S⁴

Show Affiliations

1. Department of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares university, Tehran, Iran
2. Multiple sclerosis research center, Neuroscience institute, Tehran university of medical sciences, Tehran, Iran
3. Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
4. Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Source: Multiple Sclerosis and Related Disorders Published:2022

Abstract

Background: Physical activity can improve brain health in people with multiple sclerosis (PwMS). One of the underlying mechanisms can be the modulation of gut bacteria. The association of different intensity of physical activity in a lifetime; and brain volume, lesion volume, and number, and gut bacteria counts were investigated in the current study. Methods: Forty-five PwMS were recruited, and magnetic resonance imagining was used to evaluate brain volume, lesion volume, and number. Also, stool samples were taken for evaluation faecalibacterium prausnitzii, akkermansia muciniphila, prevotella, and bacteroides count. Moreover, lifetime physical activity was assessed using the adapted version of the historical activity questionnaire. Results: Data revealed a significant association of physical activity with brain volume (r = 0.41), lesion volume (r=-0.35), lesion number (r=-0.37), akkermansia muciniphila (r=-0.34), prevotella (r = 0.52) and bacteroides (r=-0.32) count (p<0.05). Moderate-intensity of physical activity was associated with brain volume (r = 0.33), lesion volume (r=-0.38), prevotella (r = 0.35) and bacteroides (r=-0.40) count (p<0.05). Moreover, vigorous-intensity of physical activity was associated with brain volume (r = 0.38), lesion number (r=-0.39), akkermansia muciniphila (r=-0.30) and prevotella (r = 0.56) count (p<0.05). Conclusion: Our results suggest that lifetime physical activity is associated with brain health and gut bacteria count in PwMS. Additionally, the heterogeneity of the association of the physical activity intensities with the studied variables indicates the importance of using different intensities of physical activity to greater benefit from physical activity. © 2022

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Experts (# of related papers)

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Maryam Abolhasani (5)

Mohammad Ali Sahraian (5)

Style	Citing Format
MLA	Mokhtarzade M, et al.. "Lifetime Physical Activity Is Associated With Gut Bacteria and Brain Health in People With Multiple Sclerosis: Focus on Physical Activity Intensity." Multiple Sclerosis and Related Disorders, vol. 59, no. , 2022, pp. -.
APA	Mokhtarzade M, Molanouri Shamsi M, Abolhasani M, Bakhshi B, Sahraian MA, Hamzeh Shalamzari M, Soudi S (2022). Lifetime Physical Activity Is Associated With Gut Bacteria and Brain Health in People With Multiple Sclerosis: Focus on Physical Activity Intensity. Multiple Sclerosis and Related Disorders, 59(), -.
Chicago	Mokhtarzade M, Molanouri Shamsi M, Abolhasani M, Bakhshi B, Sahraian MA, Hamzeh Shalamzari M, Soudi S. "Lifetime Physical Activity Is Associated With Gut Bacteria and Brain Health in People With Multiple Sclerosis: Focus on Physical Activity Intensity." Multiple Sclerosis and Related Disorders 59, no. (2022): -.
Harvard	Mokhtarzade M et al. (2022) 'Lifetime Physical Activity Is Associated With Gut Bacteria and Brain Health in People With Multiple Sclerosis: Focus on Physical Activity Intensity', Multiple Sclerosis and Related Disorders, 59(), pp. -.
Vancouver	Mokhtarzade M, Molanouri Shamsi M, Abolhasani M, Bakhshi B, Sahraian MA, Hamzeh Shalamzari M, et al.. Lifetime Physical Activity Is Associated With Gut Bacteria and Brain Health in People With Multiple Sclerosis: Focus on Physical Activity Intensity. Multiple Sclerosis and Related Disorders. 2022;59():-.
BibTex	@article{ author = {Mokhtarzade M and Molanouri Shamsi M and Abolhasani M and Bakhshi B and Sahraian MA and Hamzeh Shalamzari M and Soudi S}, title = {Lifetime Physical Activity Is Associated With Gut Bacteria and Brain Health in People With Multiple Sclerosis: Focus on Physical Activity Intensity}, journal = {Multiple Sclerosis and Related Disorders}, volume = {59}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Mokhtarzade M AU - Molanouri Shamsi M AU - Abolhasani M AU - Bakhshi B AU - Sahraian MA AU - Hamzeh Shalamzari M AU - Soudi S TI - Lifetime Physical Activity Is Associated With Gut Bacteria and Brain Health in People With Multiple Sclerosis: Focus on Physical Activity Intensity JO - Multiple Sclerosis and Related Disorders VL - 59 IS - SP - EP - PY - 2022 ER -

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