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The Effect of Probiotics on Immune Responses and Their Therapeutic Application: A New Treatment Option for Multiple Sclerosis Publisher Pubmed



Hashemi B1 ; Abdollahi M1 ; Abbaspouraghdam S2 ; Hazrati A3 ; Malekpour K4 ; Meshgi S5 ; Kafil HS6 ; Ghazi F7 ; Yousefi M7 ; Roshangar L7 ; Ahmadi M7
Authors
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Authors Affiliations
  1. 1. Department of Bacteriology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran
  2. 2. Department of Clinical Biochemistry and Applied Cell Sciences, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  3. 3. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Biomedicine and Pharmacotherapy Published:2023


Abstract

Multiple sclerosis (MS) is known as a chronic inflammatory disease (CID) that affects the central nervous system and leads to nerve demyelination. However, the exact cause of MS is unknown, but immune system regulation and inhibiting the function of inflammatory pathways may have a beneficial effect on controlling and improving the disease. Studies show that probiotics can alter the gut microbiome, thereby improving and affecting the immune system and inflammatory responses in patients with MS. The results show that probiotics have a good effect on the recovery of patients with MS in humans and animals. The present study investigated the effect of probiotics and possible therapeutic mechanisms of probiotics on immune cells and inflammatory cytokines. This review article showed that probiotics could improve immune cells and inflammatory cytokines in patients with MS and can play an effective role in disease management and control. © 2023 The Authors
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