Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Pre- and Posttransplant Iga Anti-Fab Antibodies to Predict Long-Term Kidney Graft Survival Publisher Pubmed



Amirzargar MA1 ; Amirzargar A2 ; Basiri A3 ; Hajilooi M4 ; Roshanaei G5 ; Rajabi G1 ; Solgi G4, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Urology, Medical School, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Molecular Immunology Research Center, Medical School, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Urology Research Center, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Immunology Department, School of Medicine, Hamadan University of Medical Sciences, Mahdieh Ave, Lona Park, Hamadan, Iran
  5. 5. Research Center for Health Science, Department of Biostatistics and Epidemiology, Hamadan University of Medical Sciences, Hamadan, Iran
  6. 6. Department of Dermatology, Farshchian Hospital, Hamadan University of Medical Sciences, Hamadan, Iran

Source: Transplantation Proceedings Published:2015


Abstract

Objectives Immunologic factors are reliable markers for allograft monitoring, because of their seminal role in rejection process. One of these factors is the immunoglobulin (Ig)A anti-Fab of the IgG antibody. This study aimed to evaluate the predictive value of pre- and posttransplant levels of this marker for kidney allograft function and survival. Methods Sera samples of 59 living unrelated donor kidney recipients were collected before and after transplantation (days 7, 14, and 30) and investigated for IgA anti-Fab of IgG antibody levels using enzyme-linked immunosorbent assay in relation with allograft outcome. Results Among 59 patients, 15 cases (25%) including 10 with acute rejection and 5 with chronic rejection episodes showed graft failure during a mean of 5 years of follow-up. High posttransplant levels of IgA anti-Fab antibodies were observed more frequently in patients with stable graft function (SGF) compared with patients with graft failure (P = 2 × 10-6). None of patients with acute or chronic rejection episodes had high levels of IgA anti-Fab antibodies at day 30 posttransplant compared with the SGF group (P = 10-6 and P =.01, respectively). In addition, high levels of IgA anti-Fab antibody correlated with lesser concentration of serum creatinine at 1 month posttransplantation (P =.01). Five-year graft survival was associated with high levels of pre- and posttransplant IgA anti-Fab antibodies (P =.02 and P =.003, respectively). Conclusions Our findings indicate the protective effect of higher levels of IgA anti-Fab antibodies regarding to kidney allograft outcomes and long-term graft survival. © 2015 Elsevier Inc.
Related Docs
1. Enzyme-Linked Immunosorbent Spot (Elispot) Monitoring of Cytokine-Producing Cells for the Prediction of Acute Rejection in Renal Transplant Patients, European Cytokine Network (2017)
2. Soluble Major Histocompatibility Complex Class I Chainrelated Antigen a Level in Chronic Allograft Dysfunction, Iranian Journal of Kidney Diseases (2015)
Experts (# of related papers)
View all Related Experts
Ali Akbar Amirzargar (2)
Mahboob Lessan Pezeshki (2)