Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Turmeric Effect on Subcutaneous Insulin-Induced Amyloid Mass: An in Vivo Study Publisher Pubmed



Kheirbakhsh R1, 2 ; Chinisaz M2 ; Amanpour S3 ; Amini S2 ; Khodayari S4 ; Khodayari H5 ; Dilmaghanian A6 ; Haddadi M7 ; Ebrahimhabibi A2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Cancer Models Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Islamic Azad University, Tehran Medical Branch, Tehran, Iran
  5. 5. Pharmaceutical Sciences Branch and Pharmaceutical Sciences Research Center, Islamic Azad University, Tehran, Iran
  6. 6. Department of Basic Sciences, Division of Anatomical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  7. 7. Vali E Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Drug and Chemical Toxicology Published:2017


Abstract

Protein-derived amyloid structures are associated with a wide variety of pathologies, including neurodegenerative diseases and local amyloidoses. Reports exist on the ability of insulin to form local amyloidoses under specific conditions. In vitro-generated fibrils of insulin have been previously shown to produce amyloid-containing masses upon repetitive subcutaneous injection in mouse. The present study aimed at investigating the effect of insulin fibrils injection in rats, as well as the potential of turmeric in attenuating this process. It was found that subcutaneous amyloid-containing masses could form in rats at a faster rate compared with mice. Upon addition of turmeric to the fibrils, previous to injection, formed masses had a significantly reduced size, as well as less ordered cellular structure. In conclusion, the results of this study show the potential of turmeric in attenuation of local amyloidosis. Furthermore, we suggest that this model could be of use in screening antiamyloid compounds. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Experts (# of related papers)
Other Related Docs
11. Characterization of Arginine Preventive Effect on Heat-Induced Aggregation of Insulin, International Journal of Biological Macromolecules (2020)
15. Curcumin: A New Candidate for Melanoma Therapy?, International Journal of Cancer (2016)