Intraosseous Angiolipoma of the Mandible: A Rare Case Report Publisher

Summary: What makes intraosseous angiolipoma so rare? This study found only 8 cases reported! Accurate histopathology is crucial for proper diagnosis. #OralPathology #Angiolipoma

Mojtahedi H ; Yegane M ; Amirzadegan K ; Aminishakib P
Source: Iranian Journal of Pathology Published:2026

Abstract

Background & Objective: We report the case of an extremely rare intraosseous adipocytic tumor of the mandible. Angiolipoma is a unique variant of lipoma composed of mature fat cells with proliferating capillaries. Case Report: An asymptomatic 63-year-old patient attended a dental check-up, and a bordered radiolucency was incidentally found on the lower left side of the mandibular body. Conservative enucleation was performed with significant intraoperative bleeding. The preliminary diagnosis was central giant cell granuloma (CGCG). Histological analysis revealed that the lesion consisted of lobules of mature adipocytes interspersed with numerous vascular spaces. These findings were consistent with the diagnosis of intraosseous angiolipoma of the mandible. To the best of our knowledge, this represents the eighth case to be reported in the literature, showcasing the rarity of this lesion. Conclusion: The diagnosis of intraosseous angiolipoma in the jaws poses numerous difficulties and requires detailed histopathological examination. It is essential for oral pathologists to be familiar with such rare lesions to guarantee an accurate diagnosis. Conservative surgical enucleation of the lesion is usually the preferred treatment approach. Recognizing these atypical variants will assist pathologists in optimizing patient care through a precise and timely diagnosis and intervention. © 2026, Iranian Society of Pathology. All rights reserved.