Evaluation of Dna Methylation in Bdnf, Slc6a4, Nr3c1 and Fkbp5 Before and After Treatment With Selective Serotonin-Reuptake Inhibitor in Major Depressive Disorder

Evaluation of Dna Methylation in Bdnf, Slc6a4, Nr3c1 and Fkbp5 Before and After Treatment With Selective Serotonin-Reuptake Inhibitor in Major Depressive Disorder Publisher Pubmed

Mohammadi S¹ ; Behpajooh A¹ ; Ahmadimanesh M² ; Amini M³ ; Ghazikhansari M⁴ ; Moallem SA^{2, 6} ; Hosseini R¹ ; Nourian YH¹ ; Ghahremani MH^{1, 5}

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1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Toxicology and Poisoning Research Center, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Pharmacology and Toxicology, College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq

Source: Epigenomics Published:2022

Abstract

Aim: To identify the DNA methylation status of related genes in major depressive disorder following selective serotonin-reuptake inhibitor treatment. Materials & methods: 45 patients with major depressive disorder and 45 healthy volunteers were considered experimental and control groups, respectively. High-resolution melting real-time PCR was implemented to evaluate DNA methylation. Results: After 100 days of selective serotonin-reuptake inhibitor treatment, methylation of promoter CpG sites of BDNF, NR3C1, FKBP5 and SLC6A4 was significantly reduced. Compared with before treatment, patients' Hamilton Depression Rating Scale scores were significantly reduced after selective serotonin-reuptake inhibitor treatment (p ≤ 0.0001). Conclusion: Based on the proven effect of antidepressants on DNA methylation and gene expression, these medications can improve the treatment process and reduce depression scores after treatment. © 2022 Future Medicine Ltd.

Style	Citing Format
MLA	Mohammadi S, et al.. "Evaluation of Dna Methylation in Bdnf, Slc6a4, Nr3c1 and Fkbp5 Before and After Treatment With Selective Serotonin-Reuptake Inhibitor in Major Depressive Disorder." Epigenomics, vol. 14, no. 20, 2022, pp. 1269-1280.
APA	Mohammadi S, Behpajooh A, Ahmadimanesh M, Amini M, Ghazikhansari M, Moallem SA, Hosseini R, Nourian YH, Ghahremani MH (2022). Evaluation of Dna Methylation in Bdnf, Slc6a4, Nr3c1 and Fkbp5 Before and After Treatment With Selective Serotonin-Reuptake Inhibitor in Major Depressive Disorder. Epigenomics, 14(20), 1269-1280.
Chicago	Mohammadi S, Behpajooh A, Ahmadimanesh M, Amini M, Ghazikhansari M, Moallem SA, Hosseini R, Nourian YH, Ghahremani MH. "Evaluation of Dna Methylation in Bdnf, Slc6a4, Nr3c1 and Fkbp5 Before and After Treatment With Selective Serotonin-Reuptake Inhibitor in Major Depressive Disorder." Epigenomics 14, no. 20 (2022): 1269-1280.
Harvard	Mohammadi S et al. (2022) 'Evaluation of Dna Methylation in Bdnf, Slc6a4, Nr3c1 and Fkbp5 Before and After Treatment With Selective Serotonin-Reuptake Inhibitor in Major Depressive Disorder', Epigenomics, 14(20), pp. 1269-1280.
Vancouver	Mohammadi S, Behpajooh A, Ahmadimanesh M, Amini M, Ghazikhansari M, Moallem SA, et al.. Evaluation of Dna Methylation in Bdnf, Slc6a4, Nr3c1 and Fkbp5 Before and After Treatment With Selective Serotonin-Reuptake Inhibitor in Major Depressive Disorder. Epigenomics. 2022;14(20):1269-1280.
BibTex	@article{ author = {Mohammadi S and Behpajooh A and Ahmadimanesh M and Amini M and Ghazikhansari M and Moallem SA and Hosseini R and Nourian YH and Ghahremani MH}, title = {Evaluation of Dna Methylation in Bdnf, Slc6a4, Nr3c1 and Fkbp5 Before and After Treatment With Selective Serotonin-Reuptake Inhibitor in Major Depressive Disorder}, journal = {Epigenomics}, volume = {14}, number = {20}, pages = {1269-1280}, year = {2022} }
RIS	TY - JOUR AU - Mohammadi S AU - Behpajooh A AU - Ahmadimanesh M AU - Amini M AU - Ghazikhansari M AU - Moallem SA AU - Hosseini R AU - Nourian YH AU - Ghahremani MH TI - Evaluation of Dna Methylation in Bdnf, Slc6a4, Nr3c1 and Fkbp5 Before and After Treatment With Selective Serotonin-Reuptake Inhibitor in Major Depressive Disorder JO - Epigenomics VL - 14 IS - 20 SP - 1269 EP - 1280 PY - 2022 ER -

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