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The Role of Dna Methylation in Cancer Publisher



Shahkarami S1, 2, 3 ; Zoghi S1, 4, 5, 6 ; Rezaei N7, 8, 9
Authors
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Authors Affiliations
  1. 1. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Medical Genetics Network (MeGeNe), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria
  5. 5. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
  6. 6. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Vienna, Austria
  7. 7. Research Center for Immunodeficiencies, Children's Medical Center and Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Cancer Immunology: A Translational Medicine Context# Second Edition Published:2020


Abstract

DNA methylation is a highly characterized epigenetic mechanism, which plays a fundamental role in epigenetic disorders such as cancers. A large number of DNA methylation analysis strategies are available for assessing the DNA methylation status in order to define unique DNA methylation features and employing them as beneficial biomarkers for diagnosis, prognosis, and residual disease detecting. Furthermore, cancer therapy approaches hold promise for effective interventions with respect to reversible nature of DNA methylation aberrations. © Springer Nature Switzerland AG 2020.
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