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Analyzing and Optimizing the Adsorption of Metronidazole Antibiotic on Nano-Scale Pumice Mine Waste Based Rsm-Ccd Technique in Water Publisher



Jonidi Jafari A1, 2 ; Jafari Mansoorian H3 ; Askarpour H4 ; Salari M5 ; Eslami F2, 11 ; Faraji M6, 7 ; Shomoossi F8 ; Abdipour H9 ; Jaberi Ansari F10
Authors
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Authors Affiliations
  1. 1. Research Center for Environmental Health Technology, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Environmental Health Engineering, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Environmental Health Engineering, Faculty of Health and Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran
  4. 4. Clinical Research Development Unit, Imam Khomeini Hospital, Jiroft University of Medical Sciences, Jiroft, Iran
  5. 5. Departments of Environmental Health Engineering, School of Health, Sabzevar University of Medical Sciences, Sabzevar, Iran
  6. 6. Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran
  7. 7. Department of Environmental Health Engineering, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran
  8. 8. Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin, Iran
  9. 9. Student Research Committee, Department of Environmental Health Engineering, Hamadan University of Medical Sciences, Hamadan, Iran
  10. 10. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Student Research Committee, Jiroft University of Medical Sciences, Jiroft, Iran

Source: International Journal of Environmental Science and Technology Published:2025


Abstract

Recently, concerns have increased regarding the presence of antibiotics in water resources. This increase has been caused by the discharge of untreated or incompletely treated pharmaceutical wastewater into aquatic environments. Metronidazole is a widely used antibiotic for the treatment of infections caused by anaerobic bacteria and protozoa. The present study investigated the efficacy of nano-pumice prepared from pumice mine waste as a low-cost adsorbent for metronidazole removal from aqueous environments. The effects of input variables, including pH, contact time, nano-pumice dose, and metronidazole concentration, were investigated. The experimental design was based on central point’s using the response surface method to study adsorption. After optimizing the input variables, isotherm and kinetic studies were conducted. The properties of the adsorbent were characterized through FESEM, XRD, BET, and FTIR analyses. The results indicated that the adsorption process followed a quadratic polynomial model, with F and p values of 990.936 and less than 0.0001, respectively. Additionally, the R2 was 0.9989, and the Adj-R2 was 0.9979. The optimal conditions for achieving a removal efficiency of 94.55% and maximum adsorption capacity of 15.313 mg/g were found to be pH = 3, contact time = 60 min, adsorbent dose = 1.5 g/L, and metronidazole concentration = 20 mg/L. Furthermore, the adsorption process aligned with the Langmuir isotherm and pseudo-first-order kinetics, as indicated by R2 values of 0.9965 and 0.9859, respectively. Therefore, nano-pumice can be suggested as a natural and environmentally friendly adsorbent with significant potential for the adsorption of metronidazole and similar antibiotics from aqueous media. © The Author(s) under exclusive licence to Iranian Society of Environmentalists (IRSEN) and Science and Research Branch, Islamic Azad University 2024.
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