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Serum Levels of Interleukin-23 and 35 in Patients With and Without Type 2 Diabetes Mellitus and Chronic Periodontitis Publisher



Maboudi A1 ; Eghbaliannouzanizadeh A2 ; Seifi H2 ; Bahar A3 ; Heidari M4 ; Mohammadpour RA5 ; Abediankenari S6 ; Poorbaghi SL7 ; Sepehrimanesh M8
Authors
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Authors Affiliations
  1. 1. Department of Periodontics, Diabetes Research Center, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran
  2. 2. Student Research Committee, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Department of Internal Medicine, Diabetes Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  4. 4. Dental Implant Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Biostatistics Department, Health Faculty, Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Immunogenetics Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  7. 7. Obesity Prevention and Treatment Research Center, Shiraz University of Medical Sciences, Iran, Shiraz, Iran
  8. 8. New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, United States

Source: Caspian Journal of Internal Medicine Published:2019


Abstract

Background: Type 2 diabetes mellitus (DM) and chronic periodontitis (CP) show common pathophysiological features. We investigated the serum levels of IL-23 and IL-35 in people with type 2 DM and CP. Methods: In a cross-sectional study, 72 patients were divided into four equal groups: group A, participants without type 2 DM and CP; group B, patients with type 2 DM without CP; group C, patients with CP and without type 2 DM; and group D, patients with type 2 DM and CP. Demographic data were obtained and periodontal conditions including clinical attachment loss, bleeding on probing, plaque index, gingival index, and probing depth was evaluated on all existing teeth. Fasting blood sugar (FBS) levels, hemoglobin (Hb) A1c, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were assessed. In addition, serum levels of IL-23 and 35 were measured using enzyme-linked immunosorbent assay. Results: The serum levels of IL-23 and 35 showed no significant differences between all groups (P>0.05). A significant positive correlation between the serum concentration of IL-23 and clinical attachment loss in the control group (r: 0.548, P=0.019) was detected. A significant negative correlation between IL-35 and the plaque index in group B (r: -0.578, P=0.012), plus significant negative correlations between IL-23 with ESR (r: -0.487, P=0.040) and CRP (r: -0.498, P=0.035) in groups C and D were also detected. Conclusion: Despite significant associations of serum concentration of IL-23 and 35 with certain periodontal and inflammatory indices, neither type 2 DM nor CP differentially affects serum levels of these two cytokines. © 2019 Babol University of Medical Sciences. All rights reserved.
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