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Genetic Variants of the Il-23/Il-17 Axis and Its Association With Periodontal Disease: A Systematic Review Publisher Pubmed



Rodriguezmontano R1, 2 ; Alarconsanchez MA2, 3 ; Lomelimartinez SM4 ; Martinezbugarin CH2 ; Heboyan A5, 6, 7
Authors
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Authors Affiliations
  1. 1. Department of Health and Illness as an Individual and Collective Process, University Center of Tlajomulco, University of Guadalajara (CUTLAJO-UdeG), Tlajomulco de Zuniga, Mexico
  2. 2. Institute of Research in Dentistry, Department of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara, Guadalajara, Mexico
  3. 3. Molecular Biology Department, University Center of Health Sciences, University of Guadalajara, Guadalajara, Mexico
  4. 4. Department of Medical and Life Sciences, La Cienega University Center, University of Guadalajara, Jalisco, Mexico
  5. 5. Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
  6. 6. Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia
  7. 7. Department of Prosthodontics, School of Dentistry, Tehran University of Medical Sciences, North Karegar St, Tehran, Iran

Source: Immunity, Inflammation and Disease Published:2025


Abstract

Background: The objective of this systematic review was to identify genetic variants of the IL-23, IL-17, IL-23R and IL-17R genes and isoforms and its possible association with increased development of periodontitis and peri-implantitis. Methods: A systematic review was prepared according to the guidelines, registered in the OSF database with the registration number: 10.17605/OSF. IO/X95ZC. The electronic search was performed in four databases: PubMed, Scopus, Web of Science, and Google Scholar from 1984 until March 15th, 2024. The JBI Critical Appraisal Checklist for Case-Control Studies was used to assess the quality of included studies. Results: Eighteen papers with a case-control design were those that ultimately met the eligibility criteria. A total of 3904 individuals (2315 with periodontitis and 90 with peri-implantitis), and 1589 healthy subjects) were studied. The age range of the study population was 14–70 years, with a mean age ± (SD) of 40.43 ± 6.33 years. A total of 28 genetic variants corresponding to the IL-17A (rs 2275913, rs 3819024, rs 10484879) IL-17F (rs 763780), IL-17R (rs 879576) and IL-23R (rs 11209026) genes were analyzed in this study. Six (33.3%) studies found an association between the IL-17A 197 G/A (rs 2275913) genetic variant and peri-implantitis and periodontitis. One study (5.5%) found an association between the IL-17A rs10484879 variant and peri-implantitis and periodontitis. Conclusion: Six polymorphisms were evaluated, highlighting rs 2275913 of the cytokine IL-17A in patients with periodontitis or peri-implantitis. Only 50% of studies found an association despite having a small sample. This suggests that other factors such as the degree of disease, systemic diseases and ethnic groups studied may play a role. © 2025 The Author(s). Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.
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