Retinal Nerve Fibre Layer Thickness Is Reduced in Metabolic Syndrome Publisher Pubmed



Zarei R¹ ; Anvari P¹ ; Eslami Y¹ ; Fakhraie G¹ ; Mohammadi M¹ ; Jamali A² ; Afarideh M³ ; Ghajar A³ ; Heydarzade S¹ ; Esteghamati A³ ; Moghimi S¹ Show Affiliations
Source: Diabetic Medicine Published:2017

Abstract

Aims: To investigate retinal nerve fibre layer (RNFL) thickness in people with metabolic syndrome (MetS) and healthy controls. Methods: A cross-sectional study was performed from March 2014 to January 2016. All participants underwent anthropometric and serological biochemical measurements, ophthalmological examination, and spectral-domain optical coherence tomography (SD-OCT). Individuals with elevated intraocular pressure, glaucoma, diabetic retinopathy and other ocular disorders were excluded. T-test, Chi square and general linear models were used to analyse the data. Results: In total, 278 eyes from 139 participants were investigated [median (interquartile range) age: 37 (32−43) years]. RNFL thickness was lower in the nasal superior (107.8 ± 19.5μm) and temporal superior (135.7 ± 18.9μm) sectors in MetS group compared with the control group (114.6 ± 22.4 μm, P = 0.013 and 140.7 ± 18.2 μm, P = 0.027, respectively). After multiple adjustments for age, gender and the side of the examined [right (OD)/left (OS)] eye, MetS was independently associated with a lower RFNL thickness in the nasal superior (β = 0.20, P = 0.009) and temporal superior (β = 0.14, P = 0.048) sectors. RNFL thickness was significantly reduced in participants with higher numbers of metabolic abnormalities, independent of age, gender and the side of the examined eye (P = 0.043). Conclusion: Our findings demonstrate that MetS is independently associated with reduced RNFL thickness, suggesting that neurodegeneration is implicated in pathogenesis of MetS. © 2017 Diabetes UK