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Mucin-16 Targeted Mesoporous Nano-System for Evaluation of Cervical Cancerviadual-Modal Computed Tomography and Ultrasonography Publisher



Tarighatnia A1, 2, 3 ; Abdkarimi MH4 ; Nader ND5 ; Mehdipour T2 ; Fouladi MR3 ; Aghanejad A2 ; Ghadiri H1, 3
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Research Center for molecular and cellular imaging (RCMCI), Advanced Medical Technologies and Equipment Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Medical Imaging Department, Aalinasab Hospital, Social Security Organization (SSO), Tabriz, Iran
  5. 5. Department of Anesthesiology, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United States

Source: New Journal of Chemistry Published:2021


Abstract

Mesoporous silica-coated bismuth nanoparticles (NPs) are dual-modal contrast agents that enable detection and quantification of cervical cancers at early stages using computed tomography (CT) and ultrasonography (US). Herein, the mesoporous silica-coated bismuth NPs are synthesized using a sol-gel method and conjugated with mucin-16 aptamer (MSBi@MUC16 NPs).In vitroandin vivoCT and US modalities are used to investigate the properties of these NPs in cellular and animal models. The US/CT imaging indicated that the accumulation of aptamer-armed NPs in HeLa cells was higher than in CHO cells. The targeted NPs accumulated in the overexpressing cells were considerably higher than the non-targeted NPs in both imaging modalities. In animal models, the targeted NPs effectively circulate in the blood and undergo tumor-accumulation in the HeLa tumor-bearing animal model. The concentrations of bismuth NPs correlated linearly with both CT numbers and the mean pixel intensity (MPI) values in US images. Furthermore, the measurements from inductively coupled plasma mass spectrometry (ICP-MS) closely agreed with the CT number values obtained from major organs. Based on these data, the MSBi@MUC16 NPs are proposed as high-performance hybrid contrast agents for US/CT dual-modal imaging of cervical cancer. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2021.