The Effects of Probiotics or Synbiotics Supplementation in Women With Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials Publisher Pubmed



Heshmati J¹ ; Farsi F^{2, 3} ; Yosaee S^{4, 5} ; Razavi M⁶ ; Rezaeinejad M⁷ ; Karimie E⁷ ; Sepidarkish M⁸ Show Affiliations
Source: Probiotics and Antimicrobial Proteins Published:2019

Abstract

We searched bibliographic databases from inception through May 2018 to evaluate the effect of probiotics (or synbiotics) supplementation in women suffering from polycystic ovary syndrome (PCOS). Seven trials involving 236 women with PCOS and 235 controls were included in the meta-analysis. Comparing with the control group, probiotics (or synbiotics) may improve Quantitative insulin sensitivity check index (QUICKI) (standardized mean difference (SMD) 0.41, 95% confidence intervals (CI) 0.01 to 0.82, P = 0.04), decrease triglyceride (TG) level (mean difference (MD) − 17.51 mg/dL, 95% CI − 29.65 to − 5.36); fasting insulin: (MD − 2.14 μIU/mL, 95% CI − 4.24 to − 0.04), and increase high-density lipoprotein (HDL) (SMD 1.55 mg/dL, 95% CI 0.28 to 2.81). No significant effect of probiotics (or synbiotics) on homeostatic model assessment-insulin resistance (HOMA-IR), fasting plasma glucose (FPG), low-density lipoprotein (LDL), total cholesterol (TC), and anthropometric indices was found in women with PCOS. Although probiotic (or synbiotics) supplementation was effective on some metabolic indices, the effect was negligible and not clinically significant. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.