Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Adenoid ‘Ameloblastoma’: Clinicopathological Description of 4 Additional Braf-Negative Cases Publisher Pubmed



Khalaj F1 ; Cinel L2 ; Aminishakib P3 ; Mosavat F4 ; Soluktekkesin M5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pathology, Cancer Institute, IKHC, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pathology, Marmara University Pendik Research and Training Hospital, Istanbul, Turkey
  3. 3. Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Oral and Maxillofacial Radiology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Oral Pathology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey

Source: Journal of Stomatology# Oral and Maxillofacial Surgery Published:2023


Abstract

Objective: Adenoid ameloblastoma (AA) is an epithelial odontogenic tumor that was recognized as a separate entity in the last odontogenic classification of WHO in 2022. The etiology is unknown, and the pathogenesis remains controversial. The objective of this study is to contribute the clinicopathological features of 4 additional BRAF-negative cases to the existing literature, aiming to enhance the molecular understanding of this unique tumor in the forthcoming classification. Materials and methods: This study consists of a case series of four patients diagnosed with AA. The patients’ demographic and clinical information were collected from the universities’ medical achieves. Histopathologically, all cases were reexamined according to the latest update of the WHO odontogenic tumor classification. In addition to H&E and immunohistochemical stains, cytogenetics was also evaluated. Results: Well-defined unilocular radiolucent lesions were observed in all cases. Ameloblastoma-like components exhibited reserved nuclear polarity, suprabasal stellate reticulum-like epithelium, duct-like structure, whorls/morules, and cribriform architecture were common features. Variable immunoreactivity to CK7, CK19, CK14, p63, and p40 were determined, and proliferative activity was greater than 15%. The BRAF molecular study revealed no mutations. Conclusions: When diagnosing AA, the essential histopathological characteristics must be rigorously applied, and a significant portion of the lesion should contain these features. Additionally, despite limited molecular data, since the BRAF mutation commonly observed in ameloblastomas is not present in the majority of AA cases, we propose changing the term ameloblastoma to ameloblastic and referring to it as adenoid ameloblastic tumor in the forthcoming classification. © 2023 Elsevier Masson SAS