A Narrative Review on Therapeutic Potential of Naringenin in Colorectal Cancer: Focusing on Molecular and Biochemical Processes

A Narrative Review on Therapeutic Potential of Naringenin in Colorectal Cancer: Focusing on Molecular and Biochemical Processes Publisher Pubmed

Zamanian MY^{1, 2} ; Golmohammadi M³ ; Abdullaev B^{4, 5, 6} ; Garcia MO⁷ ; Alazbjee AAA⁸ ; Kumar A⁹ ; Mohaamed SS¹⁰ ; Hussien BM^{11, 12, 13} ; Khalaj F¹⁴ ; Hodaei SM¹⁵ ; Shirsalimi N¹ ; Moriasi G¹⁶

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1. Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2. Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
3. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Central Asian Center of Development Studies, New Uzbekistan University, Tashkent, Uzbekistan
5. School of Medicine, Central Asian University, Tashkent, Uzbekistan
6. Department of Medical Oncology and Radiology, Samarkand State Medical University, Uzbekistan
7. Universidad Estatal de Bolivar, Facultad de Ciencias de la Salud y del Ser Humano, Carrera de Enfermeria, CP, Guaranda, Ecuador
8. Collage of Medicine, Al-Ayen University, Thi-Qar, Iraq
9. Department of Nuclear and Renewable Energy, Ural Federal University Named after the First President of Russia Boris Yeltsin, Ekaterinburg, Russian Federation
10. Department of Pharmacy, Al Rafidain University College, Bagdad, Iraq
11. Medical Laboratory Technique College, the Islamic University, Najaf, Iraq
12. Medical Laboratory Technique College, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq
13. Medical Laboratory Technique College, the Islamic University of Babylon, Babylon, Iraq
14. Digestive Diseases Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
15. Student Research Committee, Arak University of Medical Sciences, Arak, Iran
16. Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Mount Kenya University, Thika, Kenya

Source: Cell Biochemistry and Function Published:2024

Abstract

Colorectal cancer (CRC) is a common and highly metastatic cancer affecting people worldwide. Drug resistance and unwanted side effects are some of the limitations of current treatments for CRC. Naringenin (NAR) is a naturally occurring compound found in abundance in various citrus fruits such as oranges, grapefruits, and tomatoes. It possesses a diverse range of pharmacological and biological properties that are beneficial for human health. Numerous studies have highlighted its antioxidant, anticancer, and anti-inflammatory activities, making it a subject of interest in scientific research. This review provides a comprehensive overview of the effects of NAR on CRC. The study's findings indicated that NAR: (1) interacts with estrogen receptors, (2) regulates the expression of genes related to the p53 signaling pathway, (3) promotes apoptosis by increasing the expression of proapoptotic genes (Bax, caspase9, and p53) and downregulation of the antiapoptotic gene Bcl2, (4) inhibits the activity of enzymes involved in cell survival and proliferation, (5) decreases cyclin D1 levels, (6) reduces the expression of cyclin-dependent kinases (Cdk4, Cdk6, and Cdk7) and antiapoptotic genes (Bcl2, x-IAP, and c-IAP-2) in CRC cells. In vitro CDK2 binding assay was also performed, showing that the NAR derivatives had better inhibitory activities on CDK2 than NAR. Based on the findings of this study, NAR is a potential therapeutic agent for CRC. Additional pharmacology and pharmacokinetics studies are required to fully elucidate the mechanisms of action of NAR and establish the most suitable dose for subsequent clinical investigations. © 2024 John Wiley & Sons Ltd.

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Style	Citing Format
MLA	Zamanian MY, et al.. "A Narrative Review on Therapeutic Potential of Naringenin in Colorectal Cancer: Focusing on Molecular and Biochemical Processes." Cell Biochemistry and Function, vol. 42, no. 3, 2024, pp. -.
APA	Zamanian MY, Golmohammadi M, Abdullaev B, Garcia MO, Alazbjee AAA, Kumar A, Mohaamed SS, Hussien BM, Khalaj F, Hodaei SM, Shirsalimi N, Moriasi G (2024). A Narrative Review on Therapeutic Potential of Naringenin in Colorectal Cancer: Focusing on Molecular and Biochemical Processes. Cell Biochemistry and Function, 42(3), -.
Chicago	Zamanian MY, Golmohammadi M, Abdullaev B, Garcia MO, Alazbjee AAA, Kumar A, Mohaamed SS, et al.. "A Narrative Review on Therapeutic Potential of Naringenin in Colorectal Cancer: Focusing on Molecular and Biochemical Processes." Cell Biochemistry and Function 42, no. 3 (2024): -.
Harvard	Zamanian MY et al. (2024) 'A Narrative Review on Therapeutic Potential of Naringenin in Colorectal Cancer: Focusing on Molecular and Biochemical Processes', Cell Biochemistry and Function, 42(3), pp. -.
Vancouver	Zamanian MY, Golmohammadi M, Abdullaev B, Garcia MO, Alazbjee AAA, Kumar A, et al.. A Narrative Review on Therapeutic Potential of Naringenin in Colorectal Cancer: Focusing on Molecular and Biochemical Processes. Cell Biochemistry and Function. 2024;42(3):-.
BibTex	@article{ author = {Zamanian MY and Golmohammadi M and Abdullaev B and Garcia MO and Alazbjee AAA and Kumar A and Mohaamed SS and Hussien BM and Khalaj F and Hodaei SM and Shirsalimi N and Moriasi G}, title = {A Narrative Review on Therapeutic Potential of Naringenin in Colorectal Cancer: Focusing on Molecular and Biochemical Processes}, journal = {Cell Biochemistry and Function}, volume = {42}, number = {3}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Zamanian MY AU - Golmohammadi M AU - Abdullaev B AU - Garcia MO AU - Alazbjee AAA AU - Kumar A AU - Mohaamed SS AU - Hussien BM AU - Khalaj F AU - Hodaei SM AU - Shirsalimi N AU - Moriasi G TI - A Narrative Review on Therapeutic Potential of Naringenin in Colorectal Cancer: Focusing on Molecular and Biochemical Processes JO - Cell Biochemistry and Function VL - 42 IS - 3 SP - EP - PY - 2024 ER -

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