Immunotherapeutic Targets in Non-Small Cell Lung Cancer

Immunotherapeutic Targets in Non-Small Cell Lung Cancer Publisher Pubmed

Sadeghirad H¹ ; Bahrami T² ; Layeghi SM³ ; Yousefi H⁴ ; Rezaei M⁵ ; Hosseinifard SR³ ; Radfar P⁵ ; Warkiani ME⁵ ; Obyrne K⁶ ; Kulasinghe A¹

Source: Immunology Published:2023

Abstract

Non-small cell lung cancer (NSCLC) is one of the most common types of cancer in the world and has a 5-year survival rate of ~20%. Immunotherapies have shown promising results leading to durable responses, however, they are only effective for a subset of patients. To determine the best therapeutic approach, a thorough and in-depth profiling of the tumour microenvironment (TME) is required. The TME is a complex network of cell types that form an interconnected network, promoting tumour cell initiation, growth and dissemination. The stroma, immune cells and endothelial cells that comprise the TME generate a plethora of cytotoxic or cytoprotective signalling pathways. In this review, we discuss immunotherapeutic targets in NSCLC tumours and how the TME may influence patients' response to immunotherapy. © 2022 The Authors. Immunology published by John Wiley & Sons Ltd.

Related Docs

View other Related Docs

1. Understanding the Tumor Microenvironment for Effective Immunotherapy, Medicinal Research Reviews (2021)

2. The Evolving Landscape of Predictive Biomarkers in Immuno-Oncology With a Focus on Spatial Technologies, Clinical and Translational Immunology (2020)

3. Tumor Microenvironment: Interactions and Therapy, Journal of Cellular Physiology (2019)

Experts (# of related papers)

View all Related Experts

Nima Rezaei (5)

Samad Farashi Bonab (1)

Style	Citing Format
MLA	Sadeghirad H, et al.. "Immunotherapeutic Targets in Non-Small Cell Lung Cancer." Immunology, vol. 168, no. 2, 2023, pp. 256-272.
APA	Sadeghirad H, Bahrami T, Layeghi SM, Yousefi H, Rezaei M, Hosseinifard SR, Radfar P, Warkiani ME, Obyrne K, Kulasinghe A (2023). Immunotherapeutic Targets in Non-Small Cell Lung Cancer. Immunology, 168(2), 256-272.
Chicago	Sadeghirad H, Bahrami T, Layeghi SM, Yousefi H, Rezaei M, Hosseinifard SR, Radfar P, Warkiani ME, Obyrne K, Kulasinghe A. "Immunotherapeutic Targets in Non-Small Cell Lung Cancer." Immunology 168, no. 2 (2023): 256-272.
Harvard	Sadeghirad H et al. (2023) 'Immunotherapeutic Targets in Non-Small Cell Lung Cancer', Immunology, 168(2), pp. 256-272.
Vancouver	Sadeghirad H, Bahrami T, Layeghi SM, Yousefi H, Rezaei M, Hosseinifard SR, et al.. Immunotherapeutic Targets in Non-Small Cell Lung Cancer. Immunology. 2023;168(2):256-272.
BibTex	@article{ author = {Sadeghirad H and Bahrami T and Layeghi SM and Yousefi H and Rezaei M and Hosseinifard SR and Radfar P and Warkiani ME and Obyrne K and Kulasinghe A}, title = {Immunotherapeutic Targets in Non-Small Cell Lung Cancer}, journal = {Immunology}, volume = {168}, number = {2}, pages = {256-272}, year = {2023} }
RIS	TY - JOUR AU - Sadeghirad H AU - Bahrami T AU - Layeghi SM AU - Yousefi H AU - Rezaei M AU - Hosseinifard SR AU - Radfar P AU - Warkiani ME AU - Obyrne K AU - Kulasinghe A TI - Immunotherapeutic Targets in Non-Small Cell Lung Cancer JO - Immunology VL - 168 IS - 2 SP - 256 EP - 272 PY - 2023 ER -

Science Communicator Platform

Authors

Abstract