Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation of Cross-Sectional Imaging Features That Aid in the Differentiation of Benign and Malignant Splenic Lesions Publisher Pubmed



Abrishami A1 ; Khalili N2, 3 ; Kooraki S4 ; Abrishami Y5 ; Grenacher L6, 7 ; Kauczor HU6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Radiology, Shahid Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Cancer Immunology Project, Universal Scientific Education and Research Network, Tehran, Iran
  4. 4. Department of Nuclear Medicine, University of California, Los Angeles, CA, United States
  5. 5. Department of Radiation Oncology, University Hospital of Augsburg, Augsburg, Germany
  6. 6. Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany
  7. 7. Conradia Radiologie Munchen, Department of Radiology, Munich, Germany

Source: European Journal of Radiology Published:2021


Abstract

Purpose: This study aimed to investigate the role of cross-sectional imaging in differentiating between benign and malignant splenic lesions based on various imaging features. Methods: Database of imaging reports from January 2015 to December 2017 were searched dedicatedly for “spleen” or “splenic” terms to identify patients with splenic lesions found either on CT or MRI. The study cohort consisted of patients who had available histological reports or had follow-up imaging for a minimum of one year. Patients were categorized into the benign subcohort if they did not have a history of extra-splenic malignancy, and had a splenic lesion(s) falling into one of these categories: benign histopathology on biopsy, stable size and enhancement, or decreased size on follow-up imaging. Those who had malignant histopathology on biopsy were included in the malignant subcohort. Various morphologic features and enhancement patterns of these lesions were carefully reviewed by two radiologists who were blinded to the final histopathologic diagnosis. Results: We identified 161 patients (54 % males, mean age ± SD = 59.7 ± 15.4) including 124 (77 %) in the benign and 37 (23 %) in the malignant subcohort. Benign lesions were more likely to be cystic (21.7 % vs 2.7 %, p < 0.001), homogenous (59.7 % vs. 29.7 %, p = 0.001) and to demonstrate well-defined borders (69.3 % vs. 29.7 % p= <0.001). Malignant lesions had significantly larger diameter (median size: 15 vs 11 mm, p = 0.03). Restricted diffusion was not seen in any of the benign lesions; however, 50 % of malignant lesions demonstrated restricted diffusion (p = 0.003). Features such as lesion distribution, presence of calcification, splenomegaly and number of lesions were not significantly different between benign and malignant lesions. Conclusion: Smaller lesion diameter, well-defined border and homogeneity favor benign nature of splenic lesions while restricted diffusion should raise suspicion for malignancy. © 2021 Elsevier B.V.
Related Docs
1. Differentiating Malignant From Benign Splenic Lesions: A Meta-Analysis and Pictorial Review of Imaging Features, Abdominal Radiology (2024)
2. Diagnostic Performance of Different Imaging Modalities for Splenic Malignancies: A Comparative Meta-Analysis, European Journal of Radiology Open (2024)
3. Prevalence and Clinical Significance of Incidental Findings in Chest and Abdominopelvic Ct Scans of Trauma Patients; a Cross-Sectional Study, American Journal of Emergency Medicine (2024)
4. Coexistence of Splenic Hemangioma and Vascular Malformation of the Vertebrae, BMC Research Notes (2016)
Experts (# of related papers)
Faeze Salahshour (2)