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The Efficacy of Hydroalcoholic Extracts of Prosopis Farcta Against Leishmania Major; [Prosopis Farcta’Nin Hidroalkolik Ekstraktinin Leishmania Major'a Karsi Etkinligi] Publisher Pubmed



Namaei MH1 ; Solgi R1 ; Rajaii T2 ; Shafaie E1 ; Karamian M3 ; Hatam G4 ; Tasa D5 ; Riahi SM6
Authors
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Authors Affiliations
  1. 1. Birjand University of Medical Sciences, Department of Medical Microbiology, Infectious Disease Research Center, Birjand, Iran
  2. 2. Mashhad University of Medical Sciences, Health Center, Mashhad, Iran
  3. 3. Zanjan University of Medical Sciences, Department of Medical Parasitology and Mycology, Zanjan, Iran
  4. 4. Basic Sciences in Infectious Diseases Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Tehran University of Medical Sciences, Department of General Surgery, Tehran, Iran
  6. 6. Birjand University of Medical Sciences, Department of Public Health, Birjand, Iran

Source: Turkiye Parazitoloji Dergisi Published:2021


Abstract

Objective: Cutaneous leishmaniasis caused by Leishmania major (L. major) is an endemic disease in Iran. The current reference drugs, including Glucantime, possess high toxicity in addition to some side-effects. Therefore, there is a growing interest in exploring biomedical plants. The goal of the present study was to evaluate the anti-leishmanial activity and cytotoxicity of hydroalcoholic extracts from Prosopis farcta (P. farcta) over promastigote and amastigote forms. Methods: This study was performed at the Iran Birjand University of Medical Sciences, during the year 2019. In this study, the hydroalcoholic extracts of the stems, leaves (LE) and fruits (FE) of P. farcta were obtained. The anti-leishmanial activity was assessed against leptomonad promastigotes and intracellular amastigotes of L. major. The cytotoxicity of these extracts was determined in murine macrophages. Results: The FE and LE of P. farcta demonstrated a significant leishmanicidal effect against L. major promastigotes with an IC50 of 0.9 mg/mL and 1.1 mg/mL, respectively. The FE showed the most anti-leishmanial activity and presented with the highest index of selectivity (SI=14.6) as an anti-leishmanial product. Infected macrophages treated using the FE showed a reduction in parasite burden by 97.3%. Conclusion: The results of the present study demonstrated the leishmanicidal activity of P. farcta on both promastigotes and intracellular amastigotes. There is a need for performing comprehensive studies on relevant animal models and to access the effects of active components of P. farcta extract on the growth of L. major. © 2021 Turkish Society for Parasitology.
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