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Effective Materials of Medicinal Plants for Leishmania Treatment in Vivo Environment Publisher



Mehrizi TZ1 ; Hamedani MP2 ; Shahmabadi HE3 ; Mirzaei M4 ; Ardestani MS5 ; Hoseini MHM6 ; Mosaffa N6 ; Khamesipour A7 ; Javanmard A8 ; Rezazadeh S9 ; Ramezani A1
Authors
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Authors Affiliations
  1. 1. Department of Clinical Research, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Microbiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  4. 4. Iran Ministry of Health and Medical Education, Deputy Ministry for Education, Academic Staff Member, Iran
  5. 5. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medical Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Researcher, Department of Nutrition, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Medicinal Plants Research Center, Institute of Medicinal Plants, Acecr, Karaj, Iran

Source: Journal of Medicinal Plants Published:2020


Abstract

Background: Treatment of leishmaniasis is a challenge due to problems such as high price and dose of the drug, drug resistance and side effects. Objective: The study aims to introduce plants compounds, which their antileishmanial effects were approved in vivo conditions. Methods: This study as a review article was performed by searching the keywords of medicinal plants with in vivo antileishmanial effects, nanocarrier, clinical trials, and mechanism of action in the well-known databases to 2018. In this study, 14 medicinal plant compounds with antileishmanial effects were reviewed and mechanism of action and their in vivo therapeutic effect were evaluated. Results: It was found that while some of these compounds had low antileishmanial effects, their efficacy against leishmaniasis was significantly increased through loading into nanocarriers. Conclusion: This study indicated that active component of medicinal plants especially along with nano carriers can be of interest for the treatment of Leishmania. © 2020 Institute of Medicinal Plants. All rights reserved.
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