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Recent Advancements to Engineer Mesenchymal Stem Cells and Their Extracellular Vesicles for Targeting and Destroying Tumors Publisher Pubmed



Karami Fath M1 ; Moayedi Banan Z2 ; Barati R3 ; Mohammadrezakhani O4 ; Ghaderi A5 ; Hatami A6 ; Ghiabi S7 ; Zeidi N8 ; Asgari K9 ; Payandeh Z10 ; Barati G11
Authors
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Authors Affiliations
  1. 1. Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
  2. 2. School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Faculty of Pharmacy, Ramsar Campus, Mazandaran University of Medical Sciences, Sari, Iran
  5. 5. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Medical Chemistry, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  8. 8. Division of Pharmaceutical Science, Long Island University, Brooklyn, NY, United States
  9. 9. Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Department Medical Biochemistry and Biophysics, Division Medical Inflammation Research, Karolinska Institute, Stockholm, Sweden
  11. 11. Stem Cell Technology Research Center, Tehran, Iran

Source: Progress in Biophysics and Molecular Biology Published:2023


Abstract

Mesenchymal stem cells (MSCs) have the ability to migrate into tumor sites and release growth factors to modulate the tumor microenvironment. MSC therapy have shown a dual role in cancers, promoting or inhibiting. However, MSCs could be used as a carrier of anticancer agents for targeted tumor therapy. Recent technical improvements also allow engineering MSCs to improve tumor-targeting properties, protect anticancer agents, and decrease the cytotoxicity of drugs. While some of MSC functions are mediated through their secretome, MSCs-derived extracellular vesicles (EVs) are also proposed as a possible viechle for cancer therapy. EVs allow efficient loading of anticancer agents and have an intrinsic ability to target tumor cells, making them suitable for targeted therapy of tumors. In addition, the specificity and selectivity of EVs to the tumor sites could be enhanced by surface modification. In this review, we addressed the current approaches used for engineering MSCs and EVs to effectively target tumor sites and deliver anticancer agents. © 2023 Elsevier Ltd
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