The Therapeutic Effects of Berberine for Gastrointestinal Cancers Publisher Pubmed



Davoodvandi A^{1, 2} ; Sadeghi S³ ; Alavi SMA⁴ ; Alavi SS⁵ ; Jafari A^{6, 7} ; Khan H⁸ ; Aschner M⁹ ; Mirzaei H³ ; Sharifi M¹⁰ ; Asemi Z³
Source: Asia-Pacific Journal of Clinical Oncology Published:2024

Abstract

Cancer is one of the most serious human health issues. Drug therapy is the major common way to treat cancer. There is a growing interest in using natural compounds to overcome drug resistance, adverse reactions, and target specificity of certain types of drugs that may affect several targets with fewer side effects and be beneficial against various types of cancer. In this regard, the use of herbal medicines alone or in combination with the main anticancer drugs is commonly available. Berberine (BBR), a nature-driven phytochemical component, is a well-known nutraceutical due to its wide variety of pharmacological activities, including antioxidant, anti-inflammatory, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, and hypolipidemic. In addition, BBR exerts anticancer activities. In present article, we summarized the information available on the therapeutic effects of BBR and its mechanisms on five types of the most prevalent gastrointestinal cancers, including esophageal, gastric, colorectal, hepatocarcinoma, and pancreatic cancers. © 2023 The Authors. Asia-Pacific Journal of Clinical Oncology published by John Wiley & Sons Australia, Ltd.