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Correlation of Biofilm Formation, Virulence Factors, and Phylogenetic Groups Among Escherichia Coli Strains Causing Urinary Tract Infection: A Global Systematic Review and Meta‑Analysis Publisher



Mirzahosseini HK1 ; Najmeddin F1 ; Najafi A2 ; Ahmadi A2 ; Sharifnia H3 ; Khaledi A4, 5 ; Mojtahedzadeh M6, 7
Authors
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Authors Affiliations
  1. 1. Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Anesthesiology and Critical Care Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Anesthesiology and Critical Care, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
  5. 5. Department of Microbiology and Immunology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  6. 6. Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Pharmaceutical Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Research in Medical Sciences Published:2023


Abstract

Background: Different virulence factors are involved in the pathogenesis of urinary tract infection (UTI) caused by Uropathogenic Escherichia coli (UPEC); hence, this study aimed to study the prevalence of biofilm formation, virulence factors, and phylogenetic groups and their correlation with biofilm formation among UPEC isolates through a systematic review and meta‑analysis. Materials and Methods: A literature search was conducted from 1, 2000, to the end of 2021 in different databases for studies that reported biofilm together with virulence genes or phylogenetic groups in UPEC isolates from patients with UTI according to PRISMA protocol. Data were analyzed by Comprehensive meta‑analysis software. Results: The pooled prevalence of biofilm formers was 74.7%. The combined prevalence of phylogenetic Groups A, B1, B2, and D (s) were reported at 19.6%, 11%, 50.7%, and 20.5%, respectively. The most common virulence genes reported worldwide were fimA, ecpA, and fimH, with a combined prevalence of 90.3%, 86.6%, and 64.9%, respectively. The pooled prevalence of biofilm formation in UPEC isolates with phylogenetic Groups A, B1, B2, D, C, and F were 12.4%, 8.7%, 33.7%, 12.4%, 2.6%, and 2.65%, respectively. Several studies showed a correlation between biofilm production and virulence genes, or phylogenetic groups. Conclusion: Regarding data obtained, the high level of combined biofilm formation (74.7%) and the presence of a positive correlation between biofilm production and virulence genes, or phylogenetic groups as reported by the most studies included in the present review, indicates an important role of biofilm in the persistence of UPEC in the UTI. © 2023 Journal of Research in Medical Sciences.
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