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Anti-Cancer Potential of Zerumbone in Cancer and Glioma: Current Trends and Future Perspectives Publisher Pubmed



Soroush A1 ; Pourhossein S2 ; Hosseingholizadeh D3 ; Hjazi A4 ; Shahhosseini R5 ; Kavoosi H6 ; Kermanshahi N7 ; Behnamrad P8 ; Ghavamikia N9 ; Dadashpour M10 ; Karkon Shayan S12
Authors
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Authors Affiliations
  1. 1. Ramsay Pharmacy Group, Melbourne, 3004, VIC, Australia
  2. 2. Department of Pharmacy, Eastern Mediterranean University, via Mersin 10, North Cyprus, Famagusta, Turkey
  3. 3. Faculty of Pharmacy, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia
  5. 5. Faculty of Medicine, Istanbul Medipol University, Istanbul, Turkey
  6. 6. Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
  7. 7. Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  8. 8. Department of Pharmaceutics, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  9. 9. Cardiology Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Medical Biotechnology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
  11. 11. Semnan University of Medical Sciences, Semnan, Iran
  12. 12. School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran

Source: Medical Oncology Published:2024


Abstract

Plant-derived immunomodulators and antitumor factors have appealed lots of attention from natural product scientists for their efficiency and safety and their important contribution to well-designed targeted drug action and delivery mechanisms. Zerumbone (ZER), the chief component of Zingiber zerumbet rhizomes, has been examined for its wide-spectrum in the treatment of multi-targeted diseases. The rhizomes have been used as food flavoring agents in numerous cuisines and in flora medication. Numerous in vivo and in vitro experiments have prepared confirmation of ZER as a potent immunomodulator as well as a potential anti-tumor agent. This review is an interesting compilation of all the important results of the research carried out to date to investigate the immunomodulatory and anticancer properties of ZER. The ultimate goal of this comprehensive review is to supply updated information and a crucial evaluation on ZER, including its chemistry and immunomodulating and antitumour properties, which may be of principal importance to supply a novel pathway for subsequent investigation to discover new agents to treat cancers and immune-related sickness. In addition, updated information on the toxicology of ZER has been summarized to support its safety profile. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
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