Lipopolysaccharide Preconditioning Prevents Acceleration of Kindling Epileptogenesis Induced by Traumatic Brain Injury

Lipopolysaccharide Preconditioning Prevents Acceleration of Kindling Epileptogenesis Induced by Traumatic Brain Injury Publisher Pubmed

Eslami M^{1, 2, 3, 4} ; Sayyah M³ ; Soleimani M¹ ; Alizadeh L⁵ ; Hadjighassem M^{6, 7}

Show Affiliations

1. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
2. Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
3. Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran
4. Department of Basic Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Shefa Neuroscience Research Center, Tehran, Iran
6. Brain and Spinal cord injury Research Center, Neuroscience Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Neuroimmunology Published:2015

Abstract

10-20% of symptomatic epilepsies are post-traumatic. We examined effect of LPS preconditioning on epileptogenesis after controlled cortical impact (CCI). LPS (0.01, 0.1 and 0.5 mg/kg) was injected i.p. to rats 5 days before induction of CCI to parieto-temporal cortex. Kindling started 24 h after CCI by i.p. injection of 30 mg/kg of pentylenetetrazole every other day until manifestation of 3 consecutive generalized seizures. CCI injury accelerated the rate of kindled seizures acquisition. LPS (0.1 and 0.5 mg/kg) prevented the acceleration of kindling. LPS preconditioning significantly decreased IL-1β and TNF-α over-expression and the number of damaged neurons in the hippocampus of traumatic rats. © 2015 Elsevier B.V..

Related Docs

View other Related Docs

1. Curcumin Lowers the Accelerated Speed of Epileptogenesis by Traumatic Brain Injury, Iranian Biomedical Journal (2024)

2. Traumatic Brain Injury Accelerates Kindling Epileptogenesis in Rats, Neurological Research (2016)

3. Neuroinflammation and Proinflammatory Cytokines in Epileptogenesis, Molecular Neurobiology (2022)

4. Epilepsy and Innate Immune System: A Possible Immunogenic Predisposition and Related Therapeutic Implications, Human Vaccines and Immunotherapeutics (2015)

5. Modafinil Exerts Anticonvulsive Effects Against Lithium-Pilocarpine-Induced Status Epilepticus in Rats: A Role for Tumor Necrosis Factor-Α and Nitric Oxide Signaling, Epilepsy and Behavior (2022)

6. Sumatriptan Reduces Severity of Status Epilepticus Induced by Lithium–Pilocarpine Through Nitrergic Transmission and 5-Ht1b/D Receptors in Rats: A Pharmacological-Based Evidence, Fundamental and Clinical Pharmacology (2021)

7. Biofluid Biomarkers in Traumatic Brain Injury: A Systematic Scoping Review, Neurocritical Care (2021)

8. Study Protocol for a Pilot Randomised Controlled Trial Evaluating the Effectiveness of Oral Trehalose on Inflammatory Factors, Oxidative Stress, Nutritional and Clinical Status in Traumatic Head Injury Patients Receiving Enteral Nutrition, BMJ Open (2022)

Experts (# of related papers)

View all Related Experts

Ahmad Reza Dehpour (2)

Mahmoud Reza Hadjighassem (2)

Style	Citing Format
MLA	Eslami M, et al.. "Lipopolysaccharide Preconditioning Prevents Acceleration of Kindling Epileptogenesis Induced by Traumatic Brain Injury." Journal of Neuroimmunology, vol. 289, no. , 2015, pp. 143-151.
APA	Eslami M, Sayyah M, Soleimani M, Alizadeh L, Hadjighassem M (2015). Lipopolysaccharide Preconditioning Prevents Acceleration of Kindling Epileptogenesis Induced by Traumatic Brain Injury. Journal of Neuroimmunology, 289(), 143-151.
Chicago	Eslami M, Sayyah M, Soleimani M, Alizadeh L, Hadjighassem M. "Lipopolysaccharide Preconditioning Prevents Acceleration of Kindling Epileptogenesis Induced by Traumatic Brain Injury." Journal of Neuroimmunology 289, no. (2015): 143-151.
Harvard	Eslami M et al. (2015) 'Lipopolysaccharide Preconditioning Prevents Acceleration of Kindling Epileptogenesis Induced by Traumatic Brain Injury', Journal of Neuroimmunology, 289(), pp. 143-151.
Vancouver	Eslami M, Sayyah M, Soleimani M, Alizadeh L, Hadjighassem M. Lipopolysaccharide Preconditioning Prevents Acceleration of Kindling Epileptogenesis Induced by Traumatic Brain Injury. Journal of Neuroimmunology. 2015;289():143-151.
BibTex	@article{ author = {Eslami M and Sayyah M and Soleimani M and Alizadeh L and Hadjighassem M}, title = {Lipopolysaccharide Preconditioning Prevents Acceleration of Kindling Epileptogenesis Induced by Traumatic Brain Injury}, journal = {Journal of Neuroimmunology}, volume = {289}, number = {}, pages = {143-151}, year = {2015} }
RIS	TY - JOUR AU - Eslami M AU - Sayyah M AU - Soleimani M AU - Alizadeh L AU - Hadjighassem M TI - Lipopolysaccharide Preconditioning Prevents Acceleration of Kindling Epileptogenesis Induced by Traumatic Brain Injury JO - Journal of Neuroimmunology VL - 289 IS - SP - 143 EP - 151 PY - 2015 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract