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Magnetite/Dextran-Functionalized Graphene Oxide Nanosheets for in Vivo Positive Contrast Magnetic Resonance Imaging Publisher



Moradi S1 ; Akhavan O2, 3 ; Tayyebi A1 ; Rahighi R2 ; Mohammadzadeh M1, 4 ; Saligheh Rad HR5
Authors
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Authors Affiliations
  1. 1. Department of Energy Engineering, Sharif University of Technology, P.O. Box 11365-8639, Tehran, Iran
  2. 2. Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran
  3. 3. Institute for Nanoscience and Nanotechnology, Sharif University of Technology, P.O. Box 14588-89694, Tehran, Iran
  4. 4. Information Communication Technology (ICT) Faculty, ICT Ministry, P.O. Box 13916-37111, Tehran, Iran
  5. 5. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, Iran

Source: RSC Advances Published:2015


Abstract

Superparamagnetic iron oxide (SPIO) nanomaterials are widely used as magnetic resonance imaging (MRI) contrast agents (CAs). These CAs significantly shorten transverse relaxation time (T2) and so decrease the intensity of the T2-weighted MRI (negative contrast imaging). However, the partial-volume effect is known to be one of the problems in negative contrast MRI. In this work, SPIO nanoparticles were modified by dextran and graphene oxide (GO) nanosheets to achieve a positive contrast MRI with high intensity. This modification resulted in shortening the longitudinal relaxation time (T1) of the SPIO nanoparticles (in addition to the T2 shortening). Using FLASH pulse sequence, T1-weighted positive contrast MRI of Wistar rats revealed that the SPIO/dextran-functionalized GO (SPIO-Dex-FGO) significantly enhanced the contrast to noise ratio (CNR) of the positive contrast MRI as compared to the common clinical positive CA, i.e., Magnevist®. In fact, based on the CNR calculations for in vivo positive contrast images it was found that the SPIO-Dex-FGO could provide the same CNR as Magnevist® at concentrations two orders of magnitudes lower than the concentrations used for Magnevist®. Therefore, SPIO-Dex-FGO can be proposed as a promising substitution for the current CAs such as Magnevist® in T1-weighted positive contrast MRI, at lower and safer concentrations. © The Royal Society of Chemistry 2015.