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Properties Evaluation of Gd2o3-Deg As New Contrast Agent Nanomagnetic Particles Comparing to Gd-Dtpa in Mri Publisher



Nikfar B1 ; Riahi Alam N1 ; Haghgoo S2 ; Gorji E2 ; Ghanaati H3 ; Rafiei B3 ; Heydarnezhadi S1 ; Khosroshahi ME4, 5
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Authors Affiliations
  1. 1. Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Pharmaceutical Department, Food and Drug Laboratory Research Center, Ministry of Health, Tehran, Iran
  3. 3. Medical Imaging Center of Imam Khomeini Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  4. 4. Laser and Nanobiophotonics Lab, Biomaterial group, Amirkabir University of Technology, Tehran, Iran
  5. 5. University of Toronto, Department of Mechanical Eng. and Indust. Eng, Toronto, Canada

Source: IFMBE Proceedings Published:2015


Abstract

Magnetic resonance imaging (MRI) is widely used for imaging purposes. However, the sensitivity and intrinsic contrast of the MRI is low. In order to improve the quality of images Gd-DTPA (commercial Magnevist) is normally. Because of some limitations of low molecular weight of gadolinium chelates, nanoparticles gadolinium based contrast agents are proposed. In this study, we synthesized Gd-DTPA and compared its effects with Gd2O3-DEG nanoparticles. The samples were prepared at concentrations of 0.3, 0.6, 0.9 and 1.2 mM respectively by adding 1.5 ml deionized water. The corresponding Gd2O3-DEG nanoparticles diameter was measured about 80 nm. An in vitro study was performed using a 1.5 T scanner with standard spin echo protocol. Clearly, the signal amplitudes in both cases were increased with the Gd concentration at constant relaxation time. Also, a linear relation between signal intensity and longitudinal relaxation rate (R1) was observed with a correlation coefficient close to 1. The values of 4.30 and 14.27 (s-1.mM-1) were achieved for Gd- DTPA and Gd2O3-DEG nanoparticles special relaxivity, respectively. © Springer International Publishing Switzerland 2015.
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