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Micrornas in Patients With Pemphigus: A Systematic Review Publisher Pubmed



Razavi Z1 ; Esmaeili N1 ; Katebian S1 ; Aryanian Z1 ; Mosayebi F1 ; Hemmati DN1 ; Kianfar N1 ; Shakoei S1
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Authors Affiliations
  1. 1. Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: International Immunopharmacology Published:2025


Abstract

Background: Pemphigus is a group of rare and severe autoimmune blistering diseases (AIBDs). MicroRNA's role in the pathogenesis of pemphigus disease has been previously studied, but MicroRNAmicroRNAs research in dermatology is still at its beginning. Methods: This review was carried out using a systematic search on PubMed, Scopus Embase, and Web of Science from 1990 to February 2025 to explore the role of microRNA in the diagnosis and severity evaluation of pemphigus disease. Results: A total of 8 studies were identified in the systematic review that indicated the expression level of 18 types of microRNA was significantly different from that of healthy people. Conclusions: The collective data presented in this review indicate that MicroRNAmicroRNAs may help diagnose and predict the course of pemphigus, while the clinical application of these findings has yet to be verified. © 2025
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