Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy

Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy Publisher Pubmed

Tavakolpour S¹ ; Mahmoudi H¹ ; Karami F² ; Elikaei Behjati S³ ; Balighi K¹ ; Abbasi M⁴ ; Salehi Farid A¹ ; Masoudi J¹ ; Balali M³ ; Daneshpazhooh M¹ ; Modarressi MH⁵

Show Affiliations

1. Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medical Genetics, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran
3. Department of Biology, School of Basic Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
4. Zhino-Gene-Pazhoohan research services co., Tehran, Iran
5. Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Dermatologic Therapy Published:2020

Abstract

Pemphigus is a rare group of autoimmune diseases, which its exact molecular pathogenesis and therapeutic biomarkers remained unknown. In this regard the expressions of eight immune-related genes was evalualted in pemphigus patients. Forty-six pemphigus patients, either new case or on minimal therapy, were recruited. The expressions of IL22, IL9, IL21, EBI3, TNFSF13B, FCGR3A, CTLA4, and PDCD1 genes were analyzed at baseline, compared with 32 healthy controls, and their changes were monitored 3 months after rituximab (RTX) therapy through Reverse Transcriptase Real-time PCR (RT-Real-time PCR). Except of IL21, which was similar in both groups, expressions of other genes were significantly lower in patients compared with the controls (P-value <.05). PDCD1, EBI3, IL21, and IL22 genes were significantly overexpressed three months following RTX administration (P-value <.05). Higher prednisolone dosage and PDAI-score were positively correlated with CTLA4 and FCGR3A expressions after 3 months, respectively (P-value =.019 and.048, respectively). Anti-desmoglein 1 (Dsg 1) titer and its positivity at baseline were associated with TNFSF13B expression, FCGR3A expressions, and the PDAI-score. Our results suggest the possible involvement of some gene expressions in pemphigus immunopathogenesis, which could be affected by RTX therapy and also might be used as prognostic biomarkers. © 2020 Wiley Periodicals LLC.

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Maryam Daneshpajooh (31)

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Style	Citing Format
MLA	Tavakolpour S, et al.. "Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy." Dermatologic Therapy, vol. 33, no. 6, 2020, pp. -.
APA	Tavakolpour S, Mahmoudi H, Karami F, Elikaei Behjati S, Balighi K, Abbasi M, Salehi Farid A, Masoudi J, Balali M, Daneshpazhooh M, Modarressi MH (2020). Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy. Dermatologic Therapy, 33(6), -.
Chicago	Tavakolpour S, Mahmoudi H, Karami F, Elikaei Behjati S, Balighi K, Abbasi M, Salehi Farid A, et al.. "Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy." Dermatologic Therapy 33, no. 6 (2020): -.
Harvard	Tavakolpour S et al. (2020) 'Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy', Dermatologic Therapy, 33(6), pp. -.
Vancouver	Tavakolpour S, Mahmoudi H, Karami F, Elikaei Behjati S, Balighi K, Abbasi M, et al.. Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy. Dermatologic Therapy. 2020;33(6):-.
BibTex	@article{ author = {Tavakolpour S and Mahmoudi H and Karami F and Elikaei Behjati S and Balighi K and Abbasi M and Salehi Farid A and Masoudi J and Balali M and Daneshpazhooh M and Modarressi MH}, title = {Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy}, journal = {Dermatologic Therapy}, volume = {33}, number = {6}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Tavakolpour S AU - Mahmoudi H AU - Karami F AU - Elikaei Behjati S AU - Balighi K AU - Abbasi M AU - Salehi Farid A AU - Masoudi J AU - Balali M AU - Daneshpazhooh M AU - Modarressi MH TI - Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy JO - Dermatologic Therapy VL - 33 IS - 6 SP - EP - PY - 2020 ER -

Style

Citing Format

MLA

Tavakolpour S, et al.. "Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy." Dermatologic Therapy, vol. 33, no. 6, 2020, pp. -.

APA

Tavakolpour S, Mahmoudi H, Karami F, Elikaei Behjati S, Balighi K, Abbasi M, Salehi Farid A, Masoudi J, Balali M, Daneshpazhooh M, Modarressi MH (2020). Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy. Dermatologic Therapy, 33(6), -.

Chicago

Tavakolpour S, Mahmoudi H, Karami F, Elikaei Behjati S, Balighi K, Abbasi M, Salehi Farid A, et al.. "Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy." Dermatologic Therapy 33, no. 6 (2020): -.

Harvard

Tavakolpour S et al. (2020) 'Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy', Dermatologic Therapy, 33(6), pp. -.

Vancouver

Tavakolpour S, Mahmoudi H, Karami F, Elikaei Behjati S, Balighi K, Abbasi M, et al.. Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy. Dermatologic Therapy. 2020;33(6):-.

BibTex

@article{ author = {Tavakolpour S and Mahmoudi H and Karami F and Elikaei Behjati S and Balighi K and Abbasi M and Salehi Farid A and Masoudi J and Balali M and Daneshpazhooh M and Modarressi MH}, title = {Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy}, journal = {Dermatologic Therapy}, volume = {33}, number = {6}, pages = {-}, year = {2020} }

RIS

TY - JOUR
AU - Tavakolpour S
AU - Mahmoudi H
AU - Karami F
AU - Elikaei Behjati S
AU - Balighi K
AU - Abbasi M
AU - Salehi Farid A
AU - Masoudi J
AU - Balali M
AU - Daneshpazhooh M
AU - Modarressi MH
TI - Investigating Expression Pattern of Eight Immune-Related Genes in Pemphigus Patients Compared With the Healthy Controls and After Rituximab Therapy: Potential Roles of Ctla4 and Fcgr3a Genes Expression in Outcomes of Rituximab Therapy
JO - Dermatologic Therapy
VL - 33
IS - 6
SP -
EP -
PY - 2020
ER -

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Abstract