Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Targeted Solid Lipid Nanoparticles Formulation for Colon Cancer Treatment and Cytotoxicity Assessment Using Ht29 Cell Line Publisher



Moghimipour E1 ; Abedini M1 ; Handali S2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Jundishapur Journal of Natural Pharmaceutical Products Published:2023


Abstract

Background: Several pharmacological effects have been attributed to thymol. However, limitations such as low solubility in water, low bioavailability, and high volatility have limited its use. Objectives: The present study aimed to prepare and characterize thymol-loaded solid lipid nanoparticles (SLNs) to improve the efficacy of thymol. Methods: Thymol-loaded SLNs were characterized by atomic force microscopy (AFM), differential scanning calorimetry (DSC), and Fourier transformed infrared spectroscopy (FT-IR). Cytotoxicity study and hemolysis assay were also performed. Results: The in vitro drug release showed a sustained manner. Also, SLNs loaded with thymol showed higher cytotoxicity than free thymol, and the hemolysis results indicated the blood biocompatibility of SLNs. Conclusions: As nanocarriers, SLNs can open a new avenue for improving the efficacy of thymol in cancer treatment. © 2023, Author(s).
Related Docs
1. Effect of Oral Administration and Topical Gel Application of Thymol and Low-Level Laser Therapy on Oxidative Stress, Inflammatory Biomarkers and Dermatitis in Patients With Type 2 Diabetes Mellitus, Bioactive Compounds in Health and Disease (2022)
2. The Synthesis, Application and Therapeutic Perspectives of Medicinal Plants-Based Solid Lipid Nanoparticles: A Comprehensive Review, Advances in Traditional Medicine (2025)
3. Evaluating the Anti-Neuropathic Effects of the Thymol-Loaded Nanofibrous Scaffold in a Rat Model of Spinal Cord Injury, Frontiers in Pharmacology (2025)
4. The Prospect of Using Nanotechnology to Prevent and Treat Infections Caused by Listeria Monocytogenes, Critical Reviews in Microbiology (2025)
5. Preparation, Statistical Optimization and in Vitro Characterization of Solid Lipid Nanoparticles As a Potential Vehicle for Transdermal Delivery of Tramadol Hydrochloride As a Hydrophilic Compound, Nanomedicine Research Journal (2020)
Experts (# of related papers)
Somayeh Handali (1)
Alireza Vatanara (1)