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Pachydermoperiostosis: A Clinicopathological Description Publisher



Tabatabaei SA1 ; Masoomi A1 ; Soleimani M1 ; Rafizadeh SM1 ; Salabati M1 ; Ahmadraji A1 ; Bohrani B1 ; Ghahvechian H1 ; Nozarian Z2
Authors
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Authors Affiliations
  1. 1. Ocular Trauma and Emergency Department, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Pathology Department, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Current Ophthalmology Published:2019


Abstract

Purpose: To report a case of pachydermoperiostosis (PDP) and a review of the literature. Methods: A 32-year-old man was referred to our clinic with bilateral eyelid swelling and blepharoptosis. On examination, marked blepharoptosis was noted, and his eyelids were found to be floppy. Systemic examination was significant for clubbing of digits, coarse acromegalic facial features, and furrowing and oiliness of the skin of scalp and forehead. Results: The patient was diagnosed as a case of PDP. On the brain MRI, the pituitary gland was enlarged, and the border of clivus was irregular. Pituitary and thyroid hormone levels were normal. He underwent bilateral lateral tarsal strip (LTS) procedure to address the eyelid laxity. Histopathologic examination revealed marked sebaceous gland hyperplasia with mucin deposition in the dermis. Conclusion: Floppy eyelid syndrome, clubbing, and acromegaloid face are main features that could lead to the diagnosis of PDP. © 2019 Iranian Society of Ophthalmology