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Peripheral Arterial Disease in Hsct Publisher



Najafi B1 ; Mohebbi B3 ; Moosavi J2 ; Firoozbakhsh P3 ; Dokhani N3 ; Dabiri M4
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Authors Affiliations
  1. 1. Department of Oncology, Guilan University of Medical Sciences, Rasht, Iran
  2. 2. Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Cardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Hematology-Oncology Department, Cancer Institute, Imam Khomeini Hospital, School of medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Cardiovascular Considerations in Hematopoietic Stem Cell Transplantation Published:2024


Abstract

Arterial diseases, mainly presenting as coronary, cerebrovascular, and peripheral artery diseases, are a group of late-onset complications of stem cell transplantation which are mostly attributed to atherosclerosis Atherosclerosis. Besides conventional risk factors, there are some transplantation-related factors that predispose recipients of allogeneic HST to atherosclerosis, including endothelial damage caused by conditioning regimen total body irradiation or graft-versus-host disease. Allogeneic hematopoietic stem cell transplant is accompanied with an increased incidence and intensity of conventional cardiovascular risk factors, including hypertension Hypertension, diabetes, and dyslipidemia, eventually leading to increased risk of arterial disorder. Detailed pathogenesis of arterial disease following HST and proper screening and preventive strategies are presented in the current chapter. © Springer Nature Switzerland AG 2024. All rights reserved.
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