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Cardiac Considerations in Hematopoietic Stem Cell Transplantation (Hsct) for Transfusion-Dependent Thalassemia: A Review Publisher



Nateghi S1 ; Rasooli A2 ; Moaddabshoar L3 ; Panahi Z4 ; Rostami MR5, 6
Authors
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Authors Affiliations
  1. 1. Department of Cardiology, Baharloo Hospital, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Department of Emergency Medicine, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  3. 3. Prevention and Cancer Control Group, Ministry of Health and Medical Education, Tehran, Iran
  4. 4. Department of Perinatology, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  5. 5. Research Institute for Oncology, Hematology and Cell Therapy (RIOHCT), Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Hematology-Oncology and Stem Cell Research Published:2025


Abstract

Hematopoietic stem cell transplantation (HSCT) is considered a potentially curative treatment for several malignant and non-malignant hematologic disorders including transfusion-dependent thalassemia (TDT). However, HSCT is associated with short-term and long-term complications. One of the recognized causes of morbidity and mortality in TDT patients is heart-related complications. Additionally, cardiac involvement is likely to be more common in patients who proceed to HSCT. So the risks of cardiac complications should be carefully weighed against the advantages of the primary disease cure. This review aims to discuss the cardiac considerations that should be kept in mind in TDT patients going through the path of HSCT. © 2025 Tehran University of Medical Sciences.
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