The Importance of Triazole Scaffold in the Development of Anticonvulsant Agents

The Importance of Triazole Scaffold in the Development of Anticonvulsant Agents Publisher Pubmed

Ayati A¹ ; Emami S² ; Foroumadi A¹

Show Affiliations

1. Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medicinal Chemistry, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Source: European Journal of Medicinal Chemistry Published:2016

Abstract

Epilepsy is one of the most important neurological disorders with high prevalence worldwide. Many epileptic patients are not completely treated with available drugs and need multiple therapies. Also, many antiepileptic drugs have shown unwanted side effects and drug interactions. Therefore there are continuing interests to find new anticonvulsant drugs. Triazole ring has been found in the structure of many compounds with diverse biological effects. Due to the success of several triazole-containing drugs that entered the pharmaceutical market as CNS-active drugs, this class of heterocyclic compounds has great importance for discovery and development of new anticonvulsant drugs. In this article, we have tried to summarize the latest efforts which have been made in the design and development of triazole-derived anticonvulsant agents. © 2016 Elsevier Masson SAS. All rights reserved.

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Style	Citing Format
MLA	Ayati A, Emami S, Foroumadi A. "The Importance of Triazole Scaffold in the Development of Anticonvulsant Agents." European Journal of Medicinal Chemistry, vol. 109, no. , 2016, pp. 380-392.
APA	Ayati A, Emami S, Foroumadi A (2016). The Importance of Triazole Scaffold in the Development of Anticonvulsant Agents. European Journal of Medicinal Chemistry, 109(), 380-392.
Chicago	Ayati A, Emami S, Foroumadi A. "The Importance of Triazole Scaffold in the Development of Anticonvulsant Agents." European Journal of Medicinal Chemistry 109, no. (2016): 380-392.
Harvard	Ayati A, Emami S, Foroumadi A (2016) 'The Importance of Triazole Scaffold in the Development of Anticonvulsant Agents', European Journal of Medicinal Chemistry, 109(), pp. 380-392.
Vancouver	Ayati A, Emami S, Foroumadi A. The Importance of Triazole Scaffold in the Development of Anticonvulsant Agents. European Journal of Medicinal Chemistry. 2016;109():380-392.
BibTex	@article{ author = {Ayati A and Emami S and Foroumadi A}, title = {The Importance of Triazole Scaffold in the Development of Anticonvulsant Agents}, journal = {European Journal of Medicinal Chemistry}, volume = {109}, number = {}, pages = {380-392}, year = {2016} }
RIS	TY - JOUR AU - Ayati A AU - Emami S AU - Foroumadi A TI - The Importance of Triazole Scaffold in the Development of Anticonvulsant Agents JO - European Journal of Medicinal Chemistry VL - 109 IS - SP - 380 EP - 392 PY - 2016 ER -

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