Increased Expression of Endoplasmic Reticulum Stress-Related Caspase-12 and Chop in the Hippocampus of Eae Mice

Increased Expression of Endoplasmic Reticulum Stress-Related Caspase-12 and Chop in the Hippocampus of Eae Mice Publisher Pubmed

Kamarehei M¹ ; Kabudanian Ardestani S¹ ; Firouzi M¹ ; Zahednasab H¹ ; Keyvani H² ; Harirchian MH³

Show Affiliations

1. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
2. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3. Iranian Centre of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Brain Research Bulletin Published:2019

Abstract

The role of endoplasmic reticulum (ER) stress has been proposed in several neurodegenerative and autoimmune diseases and may contribute to neural apoptosis. The complex role of ER stress-mediated apoptosis introduces a novel angle on multiple sclerosis (MS) research. Nevertheless, the mechanisms through which ER stress intermediates apoptosis are not entirely understood. To this aim, we examined the expression of C/EBP homologous protein (CHOP), caspase-12, and protein disulfide isomerase (PDI) in mice with experimental autoimmune encephalomyelitis (EAE). We found the upregulated expression of CHOP, caspase-12, and PDI in the brain of EAE mice in comparison to healthy mice. Furthermore, immunofluorescent dual-label staining verified elevated levels of caspase-12/CHOP in astrocytes, oligodendrocytes, and microglia in the hippocampus section of EAE mice. This study highlighted the presence of ER stress and increased activation of caspase-12 in the hippocampus of mice in response to EAE induction. Higher levels of caspase-12/CHOP in hippocampal oligodendrocytes as compared with microglia and astrocytes denote that oligodendrocytes are particularly sensitive to ER-mediated apoptosis. In conclusion, the regulation of ER stress pathway would be beneficial for the survival of oligodendrocyte. © 2019

2. C/Ebp Homologous Protein Investigation in the Serum and Cerebro-Spinal Fluid of Relapsing-Remitting Multiple Sclerosis Patients, Journal of Clinical Neuroscience (2019)

3. Mitigating Doxorubicin-Induced Hepatotoxicity in Male Rats: The Role of Aerobic Interval Training and Curcumin Supplementation in Reducing Oxidative Stress, Endoplasmic Reticulum Stress and Apoptosis, Scientific Reports (2025)

4. Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development, Contemporary Clinical Neuroscience (2023)

5. Er Stress: A Therapeutic Target in Rheumatoid Arthritis?, Trends in Pharmacological Sciences (2018)

6. Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development, Contemporary Clinical Neuroscience (2017)

Experts (# of related papers)

Mohammad Hossein Harirchian (2)

Kamran Rakhshan (1)

Style	Citing Format
MLA	Kamarehei M, et al.. "Increased Expression of Endoplasmic Reticulum Stress-Related Caspase-12 and Chop in the Hippocampus of Eae Mice." Brain Research Bulletin, vol. 147, no. , 2019, pp. 174-182.
APA	Kamarehei M, Kabudanian Ardestani S, Firouzi M, Zahednasab H, Keyvani H, Harirchian MH (2019). Increased Expression of Endoplasmic Reticulum Stress-Related Caspase-12 and Chop in the Hippocampus of Eae Mice. Brain Research Bulletin, 147(), 174-182.
Chicago	Kamarehei M, Kabudanian Ardestani S, Firouzi M, Zahednasab H, Keyvani H, Harirchian MH. "Increased Expression of Endoplasmic Reticulum Stress-Related Caspase-12 and Chop in the Hippocampus of Eae Mice." Brain Research Bulletin 147, no. (2019): 174-182.
Harvard	Kamarehei M et al. (2019) 'Increased Expression of Endoplasmic Reticulum Stress-Related Caspase-12 and Chop in the Hippocampus of Eae Mice', Brain Research Bulletin, 147(), pp. 174-182.
Vancouver	Kamarehei M, Kabudanian Ardestani S, Firouzi M, Zahednasab H, Keyvani H, Harirchian MH. Increased Expression of Endoplasmic Reticulum Stress-Related Caspase-12 and Chop in the Hippocampus of Eae Mice. Brain Research Bulletin. 2019;147():174-182.
BibTex	@article{ author = {Kamarehei M and Kabudanian Ardestani S and Firouzi M and Zahednasab H and Keyvani H and Harirchian MH}, title = {Increased Expression of Endoplasmic Reticulum Stress-Related Caspase-12 and Chop in the Hippocampus of Eae Mice}, journal = {Brain Research Bulletin}, volume = {147}, number = {}, pages = {174-182}, year = {2019} }
RIS	TY - JOUR AU - Kamarehei M AU - Kabudanian Ardestani S AU - Firouzi M AU - Zahednasab H AU - Keyvani H AU - Harirchian MH TI - Increased Expression of Endoplasmic Reticulum Stress-Related Caspase-12 and Chop in the Hippocampus of Eae Mice JO - Brain Research Bulletin VL - 147 IS - SP - 174 EP - 182 PY - 2019 ER -

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