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Coagulase-Negative Staphylococci (Cons) Meningitis: A Narrative Review of the Literature From 2000 to 2020 Publisher



Azimi T1, 3 ; Mirzadeh M2 ; Sabour S4 ; Nasser A5, 6 ; Fallah F1 ; Pourmand MR3
Authors
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Authors Affiliations
  1. 1. Pediatric Infections Research Center, Tehran, Iran
  2. 2. Department of Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Microbiology, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran
  5. 5. Clinical Microbiology Research Center, Ilam, Iran
  6. 6. Department of Medical Microbiology, School of Medicine, Ilam University of Medical Science, Ilam, Iran

Source: New Microbes and New Infections Published:2020


Abstract

Coagulase-negative staphylococci (CoNS) are recognized as comprising the main part of human normal microbiota and are rarely associated with severe and intensive infections. However, these organisms can cause a number of infections in humans, especially immunocompromised patients and neonates. Bacterial meningitis, as an important and acute infection in the central nervous system, is still a major global health challenge and a serious infectious disease, causing a high rate of mortality and morbidity. CoNS as causative agents of meningitis are generally related to trauma or direct implantation of foreign bodies and the presence of a cerebrospinal fluid shunt. Numerous epidemiologic and clinical studies have shown that different CoNS isolates such as Staphylococcus capitis, Staphylococcus lugdunensis, Staphylococcus hominis, Staphylococcus epidermidis, Staphylococcus schleiferi, Staphylococcus saprophyticus, Staphylococcus warneri and Staphylococcus haemolyticus are more frequently associated with meningitis. This study attempts to determine the role of CoNS in meningitis and reviews the reported cases of meningitis induced by CoNS from the year 2000 to 2020 in the literature. © 2020 The Authors