Preparation and Validation of [67Ga]Ga-Phytate Kit and Monte Carlo Dosimetry: An Effort Toward Developing an Impressive Lymphoscintigraphy Tracer

Preparation and Validation of [67Ga]Ga-Phytate Kit and Monte Carlo Dosimetry: An Effort Toward Developing an Impressive Lymphoscintigraphy Tracer Publisher

Bayat Z¹ ; Saeedzadeh E¹ ; Vahidfar N² ; Sadeghi M³ ; Farzenefar S² ; Daha FJ⁴ ; Salehi Y²

Show Affiliations

1. Department of Radiation Medical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
2. Department of Nuclear Medicine, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
3. Medical Physics Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
4. Radioisotope & Radiopharmaceutical Department, Radiation Application Faculty, Nuclear Science & Technology Research Institute (NSTRI), Tehran, Iran

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2022

Abstract

Radiocolloides are essential for the detection of metastatic lymph nodes in breast cancer. In this study [67Ga]Ga-phytate, as an long-lived alternative for [99mTc]Tc-radiocolloids was prepared. Standard labeling conditions for [67Ga]Ga-phytate preparation (95–100 °C, 30 min, 0.5 mg phytic acid, aqueous solutions) has been adopted (radiochemical purity: > 98 ± 2% ITLC, specific activity: 0.9–1.1 GBq/mmol). The complex is mainly cleared from the blood pool through the liver by hepatic system (> 90%) and a small percentage (< 7–8%) through the kidneys by renal excretion. Dosimetric simulations showed that the final radiopharmaceutical doses are safe for clinical administrations. © 2022, Akademiai Kiado, Budapest, Hungary.

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Style	Citing Format
MLA	Bayat Z, et al.. "Preparation and Validation of [67Ga]Ga-Phytate Kit and Monte Carlo Dosimetry: An Effort Toward Developing an Impressive Lymphoscintigraphy Tracer." Journal of Radioanalytical and Nuclear Chemistry, vol. 331, no. 2, 2022, pp. 691-700.
APA	Bayat Z, Saeedzadeh E, Vahidfar N, Sadeghi M, Farzenefar S, Daha FJ, Salehi Y (2022). Preparation and Validation of [67Ga]Ga-Phytate Kit and Monte Carlo Dosimetry: An Effort Toward Developing an Impressive Lymphoscintigraphy Tracer. Journal of Radioanalytical and Nuclear Chemistry, 331(2), 691-700.
Chicago	Bayat Z, Saeedzadeh E, Vahidfar N, Sadeghi M, Farzenefar S, Daha FJ, Salehi Y. "Preparation and Validation of [67Ga]Ga-Phytate Kit and Monte Carlo Dosimetry: An Effort Toward Developing an Impressive Lymphoscintigraphy Tracer." Journal of Radioanalytical and Nuclear Chemistry 331, no. 2 (2022): 691-700.
Harvard	Bayat Z et al. (2022) 'Preparation and Validation of [67Ga]Ga-Phytate Kit and Monte Carlo Dosimetry: An Effort Toward Developing an Impressive Lymphoscintigraphy Tracer', Journal of Radioanalytical and Nuclear Chemistry, 331(2), pp. 691-700.
Vancouver	Bayat Z, Saeedzadeh E, Vahidfar N, Sadeghi M, Farzenefar S, Daha FJ, et al.. Preparation and Validation of [67Ga]Ga-Phytate Kit and Monte Carlo Dosimetry: An Effort Toward Developing an Impressive Lymphoscintigraphy Tracer. Journal of Radioanalytical and Nuclear Chemistry. 2022;331(2):691-700.
BibTex	@article{ author = {Bayat Z and Saeedzadeh E and Vahidfar N and Sadeghi M and Farzenefar S and Daha FJ and Salehi Y}, title = {Preparation and Validation of [67Ga]Ga-Phytate Kit and Monte Carlo Dosimetry: An Effort Toward Developing an Impressive Lymphoscintigraphy Tracer}, journal = {Journal of Radioanalytical and Nuclear Chemistry}, volume = {331}, number = {2}, pages = {691-700}, year = {2022} }
RIS	TY - JOUR AU - Bayat Z AU - Saeedzadeh E AU - Vahidfar N AU - Sadeghi M AU - Farzenefar S AU - Daha FJ AU - Salehi Y TI - Preparation and Validation of [67Ga]Ga-Phytate Kit and Monte Carlo Dosimetry: An Effort Toward Developing an Impressive Lymphoscintigraphy Tracer JO - Journal of Radioanalytical and Nuclear Chemistry VL - 331 IS - 2 SP - 691 EP - 700 PY - 2022 ER -

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