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Transcriptome Analysis of Peripheral Blood Mononuclear Cells From Chronic Hepatitis B and Hepatocellular Carcinoma Patients: A Network-Based Attitude Publisher



Poortahmasebi V1, 2 ; Alavian SM3, 4 ; Nasiritoosi M5 ; Norouzi M1, 2 ; Hosseini M5 ; Jazayeri SM1, 2
Authors
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Authors Affiliations
  1. 1. Hepatitis B Molecular Laboratory, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran
  4. 4. Middle East Liver Diseases (MELD) Center, Tehran, Iran
  5. 5. Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Future Virology Published:2017


Abstract

Aim: The aim of the study was constructing a protein-protein interaction network for chronic hepatitis B (CHB) and hepatocellular carcinoma (HCC) patients. Materials & methods: Comprehensive gene expression profile of peripheral blood mononuclear cells of CHB and HCC were obtained from Gene Expression Omnibus/NCBI database. Differentially expressed genes (DEGs) of samples were analyzed using GEO2R web application. Results: The majority of DEGs in both CHB and HCC has been enriched in immune system responses. However, there was a significant disparity between the enrichment of these genes (especially genes associated with Toll-like receptor-and-TNF) in CHB-HCC compared with normal-CHB. Conclusion: The transcriptome properties of peripheral blood mononuclear cells are changed in patients with HBV-HCC. The immune response genes are the most deregulated genes in HCC patients.
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1. Integrated Analysis of Gene Expression Profiles Reveals Deregulation of the Immune Response Genes During Different Phases of Chronic Hepatitis B Infection, Hepatitis Monthly (2017)
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5. Identifying Potential New Gene Expression-Based Biomarkers in the Peripheral Blood Mononuclear Cells of Hepatitis B-Related Hepatocellular Carcinoma, Canadian Journal of Gastroenterology and Hepatology (2022)
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7. Comparative Transcriptional Signature Analysis of Peripheral Blood Mononuclear Cells in Early Stage of Hepatitis B-Related Hepatocellular Carcinoma, Hepatitis Monthly (2022)
8. Detection and Quantification of Hepatitis B Virus Genomes in Peripheral Blood Mononuclear Cells of Chronic Hepatitis B Virus Infection, Cirrhosis, and Hepatocellular Carcinoma Patients, Hepatitis Monthly (2021)
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Seyed Mohammad Jazayeri (4)
Mohsen Nasiri Toosi (2)
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