Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Sars-Cov-2 Non-Structural Protein 1(Nsp1) Mutation Virulence and Natural Selection: Evolutionary Trends in the Six Continents Publisher Pubmed



Ghaleh SS1 ; Rahimian K2 ; Mahmanzar M3 ; Mahdavi B4 ; Tokhanbigli S5 ; Sisakht MM6 ; Farhadi A7 ; Bakhtiari MM8 ; Kuehu DL3 ; Deng Y3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran
  2. 2. Bioinformatics and Computational Omics Lab (BioCOOL), Department of Biophysics. Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Department of Quantitative Health Sciences, John A, Burns School of Medicine, University of Hawaii at Manoa, Honolulu, 96813, HI, United States
  4. 4. Department of Molecular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
  5. 5. Department of Molecular and Cellular Sciences, Faculty of Advanced Sciences and Technology, pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
  6. 6. Department of Biochemistry, Erasmus University Medical Center, P.O. Box 2040, CA, Rotterdam, 3000, Netherlands
  7. 7. Department of Biology, Payame Noor University, Tehran, Iran
  8. 8. Pediatric Cell Therapy Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Virus Research Published:2023


Abstract

Objective: Rapid transmission and reproduction of RNA viruses prepare conducive conditions to have a high rate of mutations in their genetic sequence. The viral mutations make adapt the severe acute respiratory syndrome coronavirus 2 in the host environment and help the evolution of the virus then also caused a high mortality rate by the virus that threatens worldwide health. Mutations and adaptation help the virus to escape confrontations that are done against it. Methods: In the present study, we analyzed 6,510,947 sequences of non-structural protein 1 as one of the conserved regions of the virus to find out frequent mutations and substitute amino acids in comparison with the wild type. NSP1 mutations rate divided into continents were different. Results: Based on this continental categorization, E87D in global vision and also in Europe notably increased. The E87D mutation has signed up to January 2022 as the first frequent mutation observed. The remarkable mutations, H110Y and R24C have the second and third frequencies, respectively. Conclusion: According to the important role of non-structural protein 1 on the host mRNA translation, developing drug design against the protein could be so hopeful to find more effective ways the control and then treatment of the global pandemic coronavirus disease 2019. © 2022
Related Docs
1. Comparative Atlas of Sars-Cov-2 Substitution Mutations: A Focus on Iranian Strains Amidst Global Trends, Viruses (2024)
2. Immunoediting in Sars-Cov-2: Mutual Relationship Between the Virus and the Host, International Immunopharmacology (2022)
3. Covid-19 Vaccination Challenges: A Mini-Review, Human Vaccines and Immunotherapeutics (2022)
4. Structural Evolution of Delta Lineage of Sars-Cov-2, International Journal of Biological Macromolecules (2023)
5. Characterization of Sars-Cov-2 Different Variants and Related Morbidity and Mortality: A Systematic Review, European Journal of Medical Research (2021)
6. Altered Severity of the Current Sars-Cov-2 in the Kurdistan Region of Iraq, Iranian Journal of Microbiology (2020)
7. Comparison of Circulating Variants During the Beginning, Middle and the End of the 4Th Wave of Covid-19 in Tehran Province, Iran in 2021, Iranian Journal of Public Health (2023)
8. Classification of Viral Proteins Expressed by the Sars-Cov-2 Genome, Acta Microbiologica Hellenica (2022)
Experts (# of related papers)
View all Related Experts
Nazanin Zahra Shafiei Jandaghi (1)
Ahmad Nejati (1)