Personalized Image-Based Tumor Growth Prediction in a Convection–Diffusion

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Personalized Image-Based Tumor Growth Prediction in a Convection–Diffusion–Reaction Model Publisher Pubmed

Meghdadi N¹ ; Soltani M^{2, 3, 4, 5} ; Niroomandoscuii H¹ ; Yamani N⁶

Show Affiliations

1. Division of Biomechanics, Department of Mechanical Engineering, Sahand University of Technology, Tabriz, Iran
2. Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran
3. University of Waterloo, Waterloo, ON, Canada
4. Cancer Biology Research Center, Tehran University of Medical Sciences, Tehran, Iran
5. Advanced Bioengineering Initiative Center, Computational Medicine Institute, Tehran, Iran
6. Department of Neurology, Danish Headache Center, University of Copenhagen, Copenhagen, Denmark

Source: Acta Neurologica Belgica Published:2020

Abstract

Inter-individual heterogeneity of tumors leads to non-effectiveness of unique therapy plans. This issue has caused a growing interest in the field of personalized medicine and its application in tumor growth evaluation. Accordingly, in this paper, a framework of personalized medicine is presented for growth prediction of brain glioma tumors. A convection–diffusion–reaction model is used as the patient-specific tumor growth model which is associated with multimodal magnetic resonance images (MRIs). Two parameters of intracellular area fraction (ICAF) and metabolic rate have been used to incorporate the physiological data obtained from medical images into the model. The framework is tested on the data of two cases of glioma tumors to document the approach; parameter estimation is made using particle swarm optimization (PSO) and genetic algorithm (GA) and the model is evaluated by comparing the predicted tumors with the observed tumors in terms of root mean square error of the ICAF maps (IRMSE), relative area difference (RAD) and Dice’s coefficient (DC). Results show the differences of IRMSE, RAD and DC in 4.1 ∓ 1.15%, 0.099 ∓ 0.041 and 85.5 ∓ 7.5%, respectively. Survival times are estimated by assuming the tumor radius of 35 mm as the fatal burden. Results confirm that less-diffusive tumors lead to higher survival times. The represented framework makes it possible to personally predict the growth behavior of glioma tumors only based on patients’ routine MRIs and provides a basis for modeling the personalized therapy and walking in the path of personalized medicine. © 2018, Belgian Neurological Society.

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Style	Citing Format
MLA	Meghdadi N, et al.. "Personalized Image-Based Tumor Growth Prediction in a Convection–Diffusion–Reaction Model." Acta Neurologica Belgica, vol. 120, no. 1, 2020, pp. 49-57.
APA	Meghdadi N, Soltani M, Niroomandoscuii H, Yamani N (2020). Personalized Image-Based Tumor Growth Prediction in a Convection–Diffusion–Reaction Model. Acta Neurologica Belgica, 120(1), 49-57.
Chicago	Meghdadi N, Soltani M, Niroomandoscuii H, Yamani N. "Personalized Image-Based Tumor Growth Prediction in a Convection–Diffusion–Reaction Model." Acta Neurologica Belgica 120, no. 1 (2020): 49-57.
Harvard	Meghdadi N et al. (2020) 'Personalized Image-Based Tumor Growth Prediction in a Convection–Diffusion–Reaction Model', Acta Neurologica Belgica, 120(1), pp. 49-57.
Vancouver	Meghdadi N, Soltani M, Niroomandoscuii H, Yamani N. Personalized Image-Based Tumor Growth Prediction in a Convection–Diffusion–Reaction Model. Acta Neurologica Belgica. 2020;120(1):49-57.
BibTex	@article{ author = {Meghdadi N and Soltani M and Niroomandoscuii H and Yamani N}, title = {Personalized Image-Based Tumor Growth Prediction in a Convection–Diffusion–Reaction Model}, journal = {Acta Neurologica Belgica}, volume = {120}, number = {1}, pages = {49-57}, year = {2020} }
RIS	TY - JOUR AU - Meghdadi N AU - Soltani M AU - Niroomandoscuii H AU - Yamani N TI - Personalized Image-Based Tumor Growth Prediction in a Convection–Diffusion–Reaction Model JO - Acta Neurologica Belgica VL - 120 IS - 1 SP - 49 EP - 57 PY - 2020 ER -

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